Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.8.1.14 extracted from

  • Eggers, C.H.; Caimano, M.J.; Malizia, R.A.; Kariu, T.; Cusack, B.; Desrosiers, D.C.; Hazlett, K.R.; Claiborne, A.; Pal, U.; Radolf, J.D.
    The coenzyme A disulphide reductase of Borrelia burgdorferi is important for rapid growth throughout the enzootic cycle and essential for infection of the mammalian host (2011), Mol. Microbiol., 82, 679-697.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CoA-disulfide + NADH + H+ Borreliella burgdorferi
-
CoA + NAD+
-
?
CoA-disulfide + NADH + H+ Borreliella burgdorferi B31
-
CoA + NAD+
-
?

Organism

Organism UniProt Comment Textmining
Borreliella burgdorferi
-
-
-
Borreliella burgdorferi B31
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CoA-disulfide + NADH + H+
-
Borreliella burgdorferi CoA + NAD+
-
?
CoA-disulfide + NADH + H+
-
Borreliella burgdorferi B31 CoA + NAD+
-
?

Synonyms

Synonyms Comment Organism
CoADR
-
Borreliella burgdorferi
coenzyme A disulphide reductase
-
Borreliella burgdorferi

Cofactor

Cofactor Comment Organism Structure
coenzyme A
-
Borreliella burgdorferi
NADH
-
Borreliella burgdorferi

General Information

General Information Comment Organism
malfunction spirochetes lacking CoADR exhibit a growth defect under both aerobic and anaerobic conditions. Enzyme loss affects survival of spirochete in fed, but not flat tick nymphs Borreliella burgdorferi
physiological function the enzyme of Borrelia burgdorferi is necessary to maintain optimal redox ratios for CoA/CoA-disulfide and NAD+/NADH during periods of rapid replication throughout the enzootic cycle, to support thiol-disulfide homeostasis, and to indirectly protect the spirochete against peroxide-mediated membrane damage. The enzyme is also required for infectivity in mice Borreliella burgdorferi