Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(1S,3S)-3-(3,4-dichlorophenyl)-N-methyl-2,3-dihydro-1H-inden-1-amine | - |
Trypanosoma brucei | |
1-[1-(1-benzothiophen-2-yl)cyclohexyl]piperidine | - |
Trypanosoma brucei | |
indatraline | - |
Trypanosoma brucei | |
trans-4-[3-(3,4-dichlorophenyl)indan-1-yl]morpholine | - |
Trypanosoma brucei | |
trans-benzyl-[3-(3,4-dichlorophenyl)-6-methoxyindan-1-yl]amine | - |
Trypanosoma brucei | |
trans-N-[3-(3,4-dichlorophenyl)indan-1-yl]-4-methylbenzenesulfonamide | - |
Trypanosoma brucei | |
trans-N-[3-(3,4-dichlorophenyl)indan-1-yl]acetamide | - |
Trypanosoma brucei | |
trans-[3-(3,4-dibromophenyl)-6-methoxyindan-1-yl]-(3-methylbutyl)amine | - |
Trypanosoma brucei | |
trans-[3-(3,4-dichlorophenyl)-6-methoxyindan-1-yl]-(3-methylbutyl)amine | - |
Trypanosoma brucei | |
trans-[3-(3,4-dichlorophenyl)indan-1-yl]-(3,4-dichlorobenzyl)amine | - |
Trypanosoma brucei | |
trans-[3-(3,4-dichlorophenyl)indan-1-yl]-(3-methylbutyl)amine | - |
Trypanosoma brucei | |
trans-[3-(3,4-dichlorophenyl)indan-1-yl]-(4-aminobenzyl)amine | - |
Trypanosoma brucei | |
trans-[3-(3,4-dichlorophenyl)indan-1-yl]-(4-chlorobenzyl)amine | - |
Trypanosoma brucei | |
trans-[3-(3,4-dichlorophenyl)indan-1-yl]-(4-dimethylaminobenzyl)amine | - |
Trypanosoma brucei | |
trans-[3-(3,4-dichlorophenyl)indan-1-yl]-(4-methoxybenzyl)amine | - |
Trypanosoma brucei | |
trans-[3-(3,4-dichlorophenyl)indan-1-yl]-(4-methylbenzyl)amine | - |
Trypanosoma brucei | |
trans-[3-(3,4-dichlorophenyl)indan-1-yl]octylamine | - |
Trypanosoma brucei | |
trans-[3-(4-chlorophenyl)-6-methoxyindan-1-yl]-(3-methylbutyl)-amine | - |
Trypanosoma brucei | |
trans-[3-(4-methoxyphenyl)-6-methoxyindan-1-yl]-(3-methylbutyl)amine | - |
Trypanosoma brucei | |
trans-[3-(4-methylphenyl)-6-methoxyindan-1-yl]-(3-methylbutyl)-amine | - |
Trypanosoma brucei |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma brucei | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
trypanothione disulfide + NADPH + H+ | - |
Trypanosoma brucei | trypanothione + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
trypanothione reductase | - |
Trypanosoma brucei |
TryR | - |
Trypanosoma brucei |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Trypanosoma brucei |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00223 | - |
in 40 mM HEPES (pH 7.5), temperature not specified in the publication | Trypanosoma brucei | trans-[3-(3,4-dichlorophenyl)-6-methoxyindan-1-yl]-(3-methylbutyl)amine | |
0.00307 | - |
in 40 mM HEPES (pH 7.5), temperature not specified in the publication | Trypanosoma brucei | trans-benzyl-[3-(3,4-dichlorophenyl)-6-methoxyindan-1-yl]amine | |
0.00315 | - |
in 40 mM HEPES (pH 7.5), temperature not specified in the publication | Trypanosoma brucei | trans-[3-(3,4-dibromophenyl)-6-methoxyindan-1-yl]-(3-methylbutyl)amine | |
0.00405 | - |
in 40 mM HEPES (pH 7.5), temperature not specified in the publication | Trypanosoma brucei | trans-[3-(3,4-dichlorophenyl)indan-1-yl]-(3-methylbutyl)amine | |
0.00414 | - |
in 40 mM HEPES (pH 7.5), temperature not specified in the publication | Trypanosoma brucei | trans-[3-(3,4-dichlorophenyl)indan-1-yl]-(4-methoxybenzyl)amine | |
0.00494 | - |
in 40 mM HEPES (pH 7.5), temperature not specified in the publication | Trypanosoma brucei | trans-[3-(3,4-dichlorophenyl)indan-1-yl]-(4-aminobenzyl)amine | |
0.00738 | - |
in 40 mM HEPES (pH 7.5), temperature not specified in the publication | Trypanosoma brucei | trans-[3-(3,4-dichlorophenyl)indan-1-yl]-(4-dimethylaminobenzyl)amine | |
0.00793 | - |
in 40 mM HEPES (pH 7.5), temperature not specified in the publication | Trypanosoma brucei | trans-[3-(3,4-dichlorophenyl)indan-1-yl]octylamine | |
0.00884 | - |
in 40 mM HEPES (pH 7.5), temperature not specified in the publication | Trypanosoma brucei | indatraline | |
0.013 | - |
in 40 mM HEPES (pH 7.5), temperature not specified in the publication | Trypanosoma brucei | trans-[3-(3,4-dichlorophenyl)indan-1-yl]-(4-methylbenzyl)amine | |
0.0158 | - |
in 40 mM HEPES (pH 7.5), temperature not specified in the publication | Trypanosoma brucei | trans-[3-(4-chlorophenyl)-6-methoxyindan-1-yl]-(3-methylbutyl)-amine | |
0.0176 | - |
in 40 mM HEPES (pH 7.5), temperature not specified in the publication | Trypanosoma brucei | trans-[3-(3,4-dichlorophenyl)indan-1-yl]-(4-chlorobenzyl)amine | |
0.0329 | - |
in 40 mM HEPES (pH 7.5), temperature not specified in the publication | Trypanosoma brucei | trans-[3-(4-methylphenyl)-6-methoxyindan-1-yl]-(3-methylbutyl)-amine | |
0.0459 | - |
in 40 mM HEPES (pH 7.5), temperature not specified in the publication | Trypanosoma brucei | trans-[3-(3,4-dichlorophenyl)indan-1-yl]-(3,4-dichlorobenzyl)amine | |
0.125 | - |
in 40 mM HEPES (pH 7.5), temperature not specified in the publication | Trypanosoma brucei | trans-[3-(4-methoxyphenyl)-6-methoxyindan-1-yl]-(3-methylbutyl)amine | |
0.173 | - |
in 40 mM HEPES (pH 7.5), temperature not specified in the publication | Trypanosoma brucei | trans-4-[3-(3,4-dichlorophenyl)indan-1-yl]morpholine | |
0.2 | - |
IC50 above 0.2 mM, in 40 mM HEPES (pH 7.5), temperature not specified in the publication | Trypanosoma brucei | trans-N-[3-(3,4-dichlorophenyl)indan-1-yl]acetamide | |
0.2 | - |
IC50 above 0.2 mM, in 40 mM HEPES (pH 7.5), temperature not specified in the publication | Trypanosoma brucei | trans-N-[3-(3,4-dichlorophenyl)indan-1-yl]-4-methylbenzenesulfonamide |