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Literature summary for 1.8.1.12 extracted from

  • Walton, J.G.; Jones, D.C.; Kiuru, P.; Durie, A.J.; Westwood, N.J.; Fairlamb, A.H.
    Synthesis and evaluation of indatraline-based inhibitors for trypanothione reductase (2011), ChemMedChem, 6, 321-328.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
(1S,3S)-3-(3,4-dichlorophenyl)-N-methyl-2,3-dihydro-1H-inden-1-amine
-
Trypanosoma brucei
1-[1-(1-benzothiophen-2-yl)cyclohexyl]piperidine
-
Trypanosoma brucei
indatraline
-
Trypanosoma brucei
trans-4-[3-(3,4-dichlorophenyl)indan-1-yl]morpholine
-
Trypanosoma brucei
trans-benzyl-[3-(3,4-dichlorophenyl)-6-methoxyindan-1-yl]amine
-
Trypanosoma brucei
trans-N-[3-(3,4-dichlorophenyl)indan-1-yl]-4-methylbenzenesulfonamide
-
Trypanosoma brucei
trans-N-[3-(3,4-dichlorophenyl)indan-1-yl]acetamide
-
Trypanosoma brucei
trans-[3-(3,4-dibromophenyl)-6-methoxyindan-1-yl]-(3-methylbutyl)amine
-
Trypanosoma brucei
trans-[3-(3,4-dichlorophenyl)-6-methoxyindan-1-yl]-(3-methylbutyl)amine
-
Trypanosoma brucei
trans-[3-(3,4-dichlorophenyl)indan-1-yl]-(3,4-dichlorobenzyl)amine
-
Trypanosoma brucei
trans-[3-(3,4-dichlorophenyl)indan-1-yl]-(3-methylbutyl)amine
-
Trypanosoma brucei
trans-[3-(3,4-dichlorophenyl)indan-1-yl]-(4-aminobenzyl)amine
-
Trypanosoma brucei
trans-[3-(3,4-dichlorophenyl)indan-1-yl]-(4-chlorobenzyl)amine
-
Trypanosoma brucei
trans-[3-(3,4-dichlorophenyl)indan-1-yl]-(4-dimethylaminobenzyl)amine
-
Trypanosoma brucei
trans-[3-(3,4-dichlorophenyl)indan-1-yl]-(4-methoxybenzyl)amine
-
Trypanosoma brucei
trans-[3-(3,4-dichlorophenyl)indan-1-yl]-(4-methylbenzyl)amine
-
Trypanosoma brucei
trans-[3-(3,4-dichlorophenyl)indan-1-yl]octylamine
-
Trypanosoma brucei
trans-[3-(4-chlorophenyl)-6-methoxyindan-1-yl]-(3-methylbutyl)-amine
-
Trypanosoma brucei
trans-[3-(4-methoxyphenyl)-6-methoxyindan-1-yl]-(3-methylbutyl)amine
-
Trypanosoma brucei
trans-[3-(4-methylphenyl)-6-methoxyindan-1-yl]-(3-methylbutyl)-amine
-
Trypanosoma brucei

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
trypanothione disulfide + NADPH + H+
-
Trypanosoma brucei trypanothione + NADP+
-
?

Synonyms

Synonyms Comment Organism
trypanothione reductase
-
Trypanosoma brucei
TryR
-
Trypanosoma brucei

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Trypanosoma brucei

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00223
-
in 40 mM HEPES (pH 7.5), temperature not specified in the publication Trypanosoma brucei trans-[3-(3,4-dichlorophenyl)-6-methoxyindan-1-yl]-(3-methylbutyl)amine
0.00307
-
in 40 mM HEPES (pH 7.5), temperature not specified in the publication Trypanosoma brucei trans-benzyl-[3-(3,4-dichlorophenyl)-6-methoxyindan-1-yl]amine
0.00315
-
in 40 mM HEPES (pH 7.5), temperature not specified in the publication Trypanosoma brucei trans-[3-(3,4-dibromophenyl)-6-methoxyindan-1-yl]-(3-methylbutyl)amine
0.00405
-
in 40 mM HEPES (pH 7.5), temperature not specified in the publication Trypanosoma brucei trans-[3-(3,4-dichlorophenyl)indan-1-yl]-(3-methylbutyl)amine
0.00414
-
in 40 mM HEPES (pH 7.5), temperature not specified in the publication Trypanosoma brucei trans-[3-(3,4-dichlorophenyl)indan-1-yl]-(4-methoxybenzyl)amine
0.00494
-
in 40 mM HEPES (pH 7.5), temperature not specified in the publication Trypanosoma brucei trans-[3-(3,4-dichlorophenyl)indan-1-yl]-(4-aminobenzyl)amine
0.00738
-
in 40 mM HEPES (pH 7.5), temperature not specified in the publication Trypanosoma brucei trans-[3-(3,4-dichlorophenyl)indan-1-yl]-(4-dimethylaminobenzyl)amine
0.00793
-
in 40 mM HEPES (pH 7.5), temperature not specified in the publication Trypanosoma brucei trans-[3-(3,4-dichlorophenyl)indan-1-yl]octylamine
0.00884
-
in 40 mM HEPES (pH 7.5), temperature not specified in the publication Trypanosoma brucei indatraline
0.013
-
in 40 mM HEPES (pH 7.5), temperature not specified in the publication Trypanosoma brucei trans-[3-(3,4-dichlorophenyl)indan-1-yl]-(4-methylbenzyl)amine
0.0158
-
in 40 mM HEPES (pH 7.5), temperature not specified in the publication Trypanosoma brucei trans-[3-(4-chlorophenyl)-6-methoxyindan-1-yl]-(3-methylbutyl)-amine
0.0176
-
in 40 mM HEPES (pH 7.5), temperature not specified in the publication Trypanosoma brucei trans-[3-(3,4-dichlorophenyl)indan-1-yl]-(4-chlorobenzyl)amine
0.0329
-
in 40 mM HEPES (pH 7.5), temperature not specified in the publication Trypanosoma brucei trans-[3-(4-methylphenyl)-6-methoxyindan-1-yl]-(3-methylbutyl)-amine
0.0459
-
in 40 mM HEPES (pH 7.5), temperature not specified in the publication Trypanosoma brucei trans-[3-(3,4-dichlorophenyl)indan-1-yl]-(3,4-dichlorobenzyl)amine
0.125
-
in 40 mM HEPES (pH 7.5), temperature not specified in the publication Trypanosoma brucei trans-[3-(4-methoxyphenyl)-6-methoxyindan-1-yl]-(3-methylbutyl)amine
0.173
-
in 40 mM HEPES (pH 7.5), temperature not specified in the publication Trypanosoma brucei trans-4-[3-(3,4-dichlorophenyl)indan-1-yl]morpholine
0.2
-
IC50 above 0.2 mM, in 40 mM HEPES (pH 7.5), temperature not specified in the publication Trypanosoma brucei trans-N-[3-(3,4-dichlorophenyl)indan-1-yl]acetamide
0.2
-
IC50 above 0.2 mM, in 40 mM HEPES (pH 7.5), temperature not specified in the publication Trypanosoma brucei trans-N-[3-(3,4-dichlorophenyl)indan-1-yl]-4-methylbenzenesulfonamide