Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,3-bis[3-(dimethylamino)propyl]-1,5-dihydro-2H-pyrimido[4,5-beta][1,4]benzothiazine-2,4(3H)-dione | 11% growth inhibition, no inhibition of glutathione reductase | Leishmania amazonensis | |
1,3-bis[3-(dimethylamino)propyl]-1,5-dihydro-2H-pyrimido[4,5-beta][1,4]benzothiazine-2,4(3H)-dione | no inhibition of glutathione reductase | Trypanosoma cruzi | |
aspidospermine | 11% growth inhibition, no inhibition of glutathione reductase | Leishmania amazonensis | |
aspidospermine | no inhibition of glutathione reductase | Trypanosoma cruzi | |
connesine | 97% growth inhibition | Leishmania amazonensis | |
N,N-dimethyl-N-[3-(7-methoxy-1-methyl-3,4-dihydro-9H-beta-carbolin-9-yl)propyl]amine | 57% growth inhibition, no inhibition of glutathione reductase, twenty-three heterocyclic compounds are evaluated for their potential as trypanothione reductase inhibitors | Leishmania amazonensis | |
N,N-dimethyl-N-[3-(7-methoxy-1-methyl-3,4-dihydro-9H-beta-carbolin-9-yl)propyl]amine | no inhibition of glutathione reductase, twenty-three heterocyclic compounds are evaluated for their potential as trypanothione reductase inhibitors | Trypanosoma cruzi |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Leishmania amazonensis | - |
- |
- |
Trypanosoma cruzi | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
trypanothione + 5,5'-dithiobis-(2-nitrobenzoic acid) | inhibitors are tested using the recombinant enzyme | Trypanosoma cruzi | trypanothione disulfide + thionitrobenzoate | - |
? | |
trypanothione + 5,5'-dithiobis-(2-nitrobenzoic acid) | inhibitors are tested using the recombinant enzyme | Leishmania amazonensis | trypanothione disulfide + thionitrobenzoate | - |
? | |
trypanothione + NADP+ | - |
Trypanosoma cruzi | trypanothione disulfide + NADPH + H+ | - |
? | |
trypanothione + NADP+ | - |
Leishmania amazonensis | trypanothione disulfide + NADPH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
trypanothione reductase | TR | Trypanosoma cruzi |
trypanothione reductase | TR | Leishmania amazonensis |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0269 | - |
1,3-bis[3-(dimethylamino)propyl]-1,5-dihydro-2H-pyrimido[4,5-beta][1,4]benzothiazine-2,4(3H)-dione | - |
Trypanosoma cruzi | |
0.035 | - |
N,N-dimethyl-N-[3-(7-methoxy-1-methyl-3,4-dihydro-9H-beta-carbolin-9-yl)propyl]amine | - |
Trypanosoma cruzi | |
0.0646 | - |
aspidospermine | - |
Trypanosoma cruzi |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0904 | - |
- |
Leishmania amazonensis | aspidospermine |