Application | Comment | Organism |
---|---|---|
medicine | promising TryR inhibitors | Leishmania donovani |
medicine | promising TryR inhibitors | Trypanosoma cruzi |
medicine | promising TryR inhibitors | Trypanosoma brucei rhodesiense |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-[2-(7-chloro-quinolin-4-ylamino)-ethyl]-1-[2-(N'',N''-dimethyl-aminomethyl)-ferrocenylmethyl]-3-p-chloro-phenyl-urea | ferrocenic 4-aminoquinoline urea compound 9, growth inhibition | Leishmania donovani | |
1-[2-(7-chloro-quinolin-4-ylamino)-ethyl]-1-[2-(N'',N''-dimethyl-aminomethyl)-ferrocenylmethyl]-3-p-chloro-phenyl-urea | ferrocenic 4-aminoquinoline urea compound 9, growth inhibition | Trypanosoma brucei rhodesiense | |
1-[2-(7-chloro-quinolin-4-ylamino)-ethyl]-1-[2-(N'',N''-dimethyl-aminomethyl)-ferrocenylmethyl]-3-p-chloro-phenyl-urea | ferrocenic 4-aminoquinoline urea compound 9, enzyme and growth inhibition | Trypanosoma cruzi | |
1-[2-(7-chloro-quinolin-4-ylamino)-ethyl]-1-[2-(N'',N''-dimethyl-aminomethyl)ferrocenylmethyl]-3-[2,6-bis-(trifluoromethyl)-phenyl]-urea | ferrocenic 4-aminoquinoline urea compound 8 | Trypanosoma cruzi | |
1-[2-(7-chloro-quinolin-4-ylamino)-ethyl]-1-[2-(N'',N''-dimethylaminomethyl)-ferrocenylmethyl]-3-p-methoxyphenyl-urea | ferrocenic 4-aminoquinoline urea compound 6, growth inhibition | Leishmania donovani | |
1-[2-(7-chloro-quinolin-4-ylamino)-ethyl]-1-[2-(N'',N''-dimethylaminomethyl)-ferrocenylmethyl]-3-p-methoxyphenyl-urea | ferrocenic 4-aminoquinoline urea compound 6, growth inhibition | Trypanosoma brucei rhodesiense | |
1-[2-(7-chloro-quinolin-4-ylamino)-ethyl]-1-[2-(N'',N''-dimethylaminomethyl)-ferrocenylmethyl]-3-p-methoxyphenyl-urea | ferrocenic 4-aminoquinoline urea compound 6, enzyme and growth inhibition | Trypanosoma cruzi | |
1-[2-(7-chloro-quinolin-4-ylamino)-ethyl]-1-[2-(N'',N''-dimethylaminomethyl)-ferrocenylmethyl]-3-p-tolyl-urea | ferrocenic 4-aminoquinoline urea compound 5 | Trypanosoma cruzi | |
1-[2-(7-chloro-quinolin-4-ylamino)-ethyl]-1-[2-(N'',N''-dimethylaminomethyl)-ferrocenylmethyl]-3-[2,4-bis-(trifluoromethyl)-phenyl]-urea | ferrocenic 4-aminoquinoline urea compound 7 | Trypanosoma cruzi | |
3-benzyl-1-[2-(7-chloro-quinolin-4-ylamino)-ethyl]-1-[2-(N'',N''-dimethylaminomethyl)-ferrocenylmethyl]urea | growth inhibition | Leishmania donovani | |
3-benzyl-1-[2-(7-chloro-quinolin-4-ylamino)-ethyl]-1-[2-(N'',N''-dimethylaminomethyl)-ferrocenylmethyl]urea | growth inhibition | Trypanosoma brucei rhodesiense | |
3-benzyl-1-[2-(7-chloro-quinolin-4-ylamino)-ethyl]-1-[2-(N'',N''-dimethylaminomethyl)-ferrocenylmethyl]urea | enzyme and growth inhibition | Trypanosoma cruzi | |
3-Benzyl-1-[3-(7-chloro-quinolin-4-ylamino)-propyl]-1-[2-(N'',N''-dimethylaminomethyl)-ferrocenylmethyl]urea | - |
Trypanosoma cruzi | |
3-Benzyl-1-[4-(7-chloro-quinolin-4-ylamino)-butyl]-1-[2-(N'',N''-dimethylaminomethyl)-ferrocenylmethyl]urea | - |
Trypanosoma cruzi | |
3-Benzyl-1-[6-(7-chloro-quinolin-4-ylamino)-hexyl]-1-[2-(N'',N''-dimethylaminomethyl)-ferrocenylmethyl]urea | - |
Trypanosoma cruzi | |
benznidazole | growth inhibition | Trypanosoma cruzi | |
Chloroquine | - |
Trypanosoma cruzi | |
N-(7-Chloro-quinolin-4-yl)-N'-[2-(N'',N''-dimethyl-aminomethyl)ferrocenylmethyl]-butane-1,4-diamine | - |
Trypanosoma cruzi | |
N-(7-Chloro-quinolin-4-yl)-N'-[2-(N'',N''-dimethyl-aminomethyl)ferrocenylmethyl]-ethane-1,2-diamine | enzyme and growth inhibition | Trypanosoma cruzi | |
N-(7-Chloro-quinolin-4-yl)-N'-[2-(N'',N''-dimethyl-aminomethyl)ferrocenylmethyl]-hexane-1,6-diamine | - |
Trypanosoma cruzi | |
N-(7-Chloro-quinolin-4-yl)-N'-[2-(N'',N''-dimethyl-aminomethyl)ferrocenylmethyl]-propane-1,3-diamine | - |
Trypanosoma cruzi | |
N-(7-Chloro-quinolin-4-yl)-N'-[2-(N'',N''-dimethylaminomethyl)ferrocenylmethyl]-ethane-1,2-diamine | growth inhibition | Leishmania donovani | |
N-(7-Chloro-quinolin-4-yl)-N'-[2-(N'',N''-dimethylaminomethyl)ferrocenylmethyl]-ethane-1,2-diamine | growth inhibition | Trypanosoma brucei rhodesiense | |
Pentamidine | growth inhibition | Trypanosoma brucei rhodesiense | |
pentostam | growth inhibition | Leishmania donovani |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Leishmania donovani | - |
- |
- |
Trypanosoma brucei rhodesiense | - |
- |
- |
Trypanosoma cruzi | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
trypanothione + NADP+ | using the recombinant enzyme | Leishmania donovani | trypanothione disulfide + NADPH + H+ | - |
? | |
trypanothione + NADP+ | using the recombinant enzyme | Trypanosoma cruzi | trypanothione disulfide + NADPH + H+ | - |
? | |
trypanothione + NADP+ | using the recombinant enzyme | Trypanosoma brucei rhodesiense | trypanothione disulfide + NADPH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
trypanothione reductase | - |
Trypanosoma cruzi |
trypanothione reductase | - |
Trypanosoma brucei rhodesiense |
trypanothione reductase | TryR | Leishmania donovani |
TryR | - |
Trypanosoma cruzi |
TryR | - |
Trypanosoma brucei rhodesiense |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.002 | - |
- |
Trypanosoma cruzi | 1-[2-(7-chloro-quinolin-4-ylamino)-ethyl]-1-[2-(N'',N''-dimethyl-aminomethyl)ferrocenylmethyl]-3-[2,6-bis-(trifluoromethyl)-phenyl]-urea | |
0.0021 | - |
- |
Trypanosoma cruzi | N-(7-Chloro-quinolin-4-yl)-N'-[2-(N'',N''-dimethyl-aminomethyl)ferrocenylmethyl]-hexane-1,6-diamine | |
0.0023 | - |
- |
Trypanosoma cruzi | 1-[2-(7-chloro-quinolin-4-ylamino)-ethyl]-1-[2-(N'',N''-dimethylaminomethyl)-ferrocenylmethyl]-3-p-methoxyphenyl-urea | |
0.0024 | - |
- |
Trypanosoma cruzi | 3-Benzyl-1-[6-(7-chloro-quinolin-4-ylamino)-hexyl]-1-[2-(N'',N''-dimethylaminomethyl)-ferrocenylmethyl]urea | |
0.0025 | - |
- |
Trypanosoma cruzi | 1-[2-(7-chloro-quinolin-4-ylamino)-ethyl]-1-[2-(N'',N''-dimethyl-aminomethyl)-ferrocenylmethyl]-3-p-chloro-phenyl-urea | |
0.0027 | - |
- |
Trypanosoma cruzi | N-(7-Chloro-quinolin-4-yl)-N'-[2-(N'',N''-dimethyl-aminomethyl)ferrocenylmethyl]-butane-1,4-diamine | |
0.0032 | - |
- |
Trypanosoma cruzi | 3-Benzyl-1-[3-(7-chloro-quinolin-4-ylamino)-propyl]-1-[2-(N'',N''-dimethylaminomethyl)-ferrocenylmethyl]urea | |
0.0033 | - |
- |
Trypanosoma cruzi | 3-Benzyl-1-[4-(7-chloro-quinolin-4-ylamino)-butyl]-1-[2-(N'',N''-dimethylaminomethyl)-ferrocenylmethyl]urea | |
0.0068 | - |
- |
Trypanosoma cruzi | N-(7-Chloro-quinolin-4-yl)-N'-[2-(N'',N''-dimethyl-aminomethyl)ferrocenylmethyl]-propane-1,3-diamine | |
0.0105 | - |
- |
Trypanosoma cruzi | 1-[2-(7-chloro-quinolin-4-ylamino)-ethyl]-1-[2-(N'',N''-dimethylaminomethyl)-ferrocenylmethyl]-3-[2,4-bis-(trifluoromethyl)-phenyl]-urea | |
0.015 | - |
- |
Trypanosoma cruzi | 3-benzyl-1-[2-(7-chloro-quinolin-4-ylamino)-ethyl]-1-[2-(N'',N''-dimethylaminomethyl)-ferrocenylmethyl]urea | |
0.0476 | - |
- |
Trypanosoma cruzi | N-(7-Chloro-quinolin-4-yl)-N'-[2-(N'',N''-dimethyl-aminomethyl)ferrocenylmethyl]-ethane-1,2-diamine |