Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | activity is dependent on a redox-active cysteine at the active centre | Trypanosoma brucei | |
additional information | activity is dependent on a redox-active cysteine at the active centre | Leishmania donovani | |
additional information | activity is dependent on a redox-active cysteine at the active centre | Trypanosoma cruzi |
Application | Comment | Organism |
---|---|---|
medicine | - |
Trypanosoma brucei |
medicine | good target for structure/function studies and trypanicidal inhibitor design | Trypanosoma cruzi |
medicine | potential target for drug design against trypanosomiasis | Trypanosoma cruzi |
medicine | target for rational approach to design new anti-leishmanial chemotherapeutic agents | Leishmania donovani |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3,3'-[polyaminobis(carbonylalkyl)]bis(1,4-naphthoquinone) derivatives | - |
Trypanosoma cruzi | |
juglone | - |
Leishmania donovani | |
juglone | - |
Trypanosoma brucei | |
juglone | - |
Trypanosoma cruzi | |
juglone derivatives | - |
Leishmania donovani | |
juglone derivatives | - |
Trypanosoma brucei | |
juglone derivatives | - |
Trypanosoma cruzi | |
menadione | - |
Trypanosoma cruzi | |
menadione derivatives | - |
Leishmania donovani | |
menadione derivatives | - |
Leishmania infantum | |
menadione derivatives | - |
Trypanosoma brucei | |
menadione derivatives | - |
Trypanosoma cruzi | |
Plumbagin | - |
Trypanosoma brucei | |
Plumbagin | - |
Trypanosoma cruzi | |
plumbagin derivatives | - |
Leishmania donovani | |
plumbagin derivatives | - |
Leishmania infantum | |
plumbagin derivatives | - |
Trypanosoma brucei | |
plumbagin derivatives | - |
Trypanosoma cruzi |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
trypanothione disulfide + NADPH | Trypanosoma brucei | - |
trypanothione + NADP+ | - |
? | |
trypanothione disulfide + NADPH | Leishmania donovani | - |
trypanothione + NADP+ | - |
? | |
trypanothione disulfide + NADPH | Leishmania infantum | - |
trypanothione + NADP+ | - |
? | |
trypanothione disulfide + NADPH | Trypanosoma cruzi | - |
trypanothione + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Leishmania donovani | - |
- |
- |
Leishmania infantum | - |
- |
- |
Trypanosoma brucei | - |
- |
- |
Trypanosoma cruzi | P28593 | - |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
trypanothione + NADP+ = trypanothione disulfide + NADPH + H+ | molecular modeling of inhibitor binding using X-ray data | Trypanosoma cruzi |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
glutathionylspermidine disulfide + NADPH | - |
Leishmania donovani | 2-glutathionylspermidine + NADP+ | - |
? | |
glutathionylspermidine disulfide + NADPH | - |
Trypanosoma cruzi | 2-glutathionylspermidine + NADP+ | - |
? | |
additional information | serve as subversive substrates in redox cycling activity: 3,3'-[polyaminobis(carbonylalkyl)]bis(1,4-naphthoquinone) derivatives, inhibitory and substrate activity depending on spacer length | Trypanosoma cruzi | ? | - |
? | |
trypanothione disulfide + NADPH | - |
Trypanosoma brucei | trypanothione + NADP+ | - |
? | |
trypanothione disulfide + NADPH | - |
Leishmania donovani | trypanothione + NADP+ | - |
? | |
trypanothione disulfide + NADPH | - |
Leishmania infantum | trypanothione + NADP+ | - |
? | |
trypanothione disulfide + NADPH | - |
Trypanosoma cruzi | trypanothione + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TR | - |
Leishmania donovani |
TR | - |
Trypanosoma cruzi |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Trypanosoma brucei | |
FAD | - |
Leishmania donovani | |
FAD | - |
Leishmania infantum | |
FAD | - |
Trypanosoma cruzi | |
NADPH | - |
Trypanosoma brucei | |
NADPH | - |
Leishmania donovani | |
NADPH | - |
Leishmania infantum | |
NADPH | - |
Trypanosoma cruzi |