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Literature summary for 1.8.1.12 extracted from

  • Bond, C.S.; Zhang, Y.; Berriman, M.; Cunningham, M.L.; Fairlamb, A.H.; Hunter, W.N.
    Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors (1999), Structure, 7, 81-89.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information activity is dependent on a redox-active cysteine at the active centre Trypanosoma cruzi

Application

Application Comment Organism
medicine good target for structure/function studies and trypanicidal inhibitor design Trypanosoma cruzi

Crystallization (Commentary)

Crystallization (Comment) Organism
substrate binding and crystal structure in complex with trypanothione disulfide, molecular modeling with potential inhibitors Trypanosoma cruzi

Inhibitors

Inhibitors Comment Organism Structure
lunarine specific Trypanosoma cruzi

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi
-
-
-

Reaction

Reaction Comment Organism Reaction ID
trypanothione + NADP+ = trypanothione disulfide + NADPH + H+ substrate binding mechanism, complex structure analysis, protease-like catalytic triade and electronic induced fit Trypanosoma cruzi

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
trypanothione disulfide + NADPH
-
Trypanosoma cruzi trypanothione + NADP+
-
?

Synonyms

Synonyms Comment Organism
TR
-
Trypanosoma cruzi

Cofactor

Cofactor Comment Organism Structure
FAD
-
Trypanosoma cruzi
NADPH
-
Trypanosoma cruzi

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.144
-
lunarine
-
Trypanosoma cruzi