Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | activity is dependent on a redox-active cysteine at the active centre | Trypanosoma cruzi |
Application | Comment | Organism |
---|---|---|
medicine | good target for structure/function studies and trypanicidal inhibitor design | Trypanosoma cruzi |
Crystallization (Comment) | Organism |
---|---|
substrate binding and crystal structure in complex with trypanothione disulfide, molecular modeling with potential inhibitors | Trypanosoma cruzi |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
lunarine | specific | Trypanosoma cruzi |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma cruzi | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
trypanothione + NADP+ = trypanothione disulfide + NADPH + H+ | substrate binding mechanism, complex structure analysis, protease-like catalytic triade and electronic induced fit | Trypanosoma cruzi |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
trypanothione disulfide + NADPH | - |
Trypanosoma cruzi | trypanothione + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TR | - |
Trypanosoma cruzi |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Trypanosoma cruzi | |
NADPH | - |
Trypanosoma cruzi |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.144 | - |
lunarine | - |
Trypanosoma cruzi |