Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | activity is dependent on a redox-active cysteine at the active centre | Crithidia fasciculata | |
additional information | activity is dependent on a redox-active cysteine at the active centre | Trypanosoma cruzi | |
additional information | activity is dependent on a redox-active cysteine at the active centre | Trypanosoma congolense |
Application | Comment | Organism |
---|---|---|
medicine | potential target for drug design against trypanosomiasis | Crithidia fasciculata |
medicine | potential target for drug design against trypanosomiasis | Trypanosoma cruzi |
medicine | potential target for drug design against trypanosomiasis | Trypanosoma congolense |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
nifurtimox | weak inhibitor | Trypanosoma cruzi |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Crithidia fasciculata | - |
insect-parasitic trypanosomatid | - |
Trypanosoma congolense | - |
- |
- |
Trypanosoma cruzi | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
trypanothione + NADP+ = trypanothione disulfide + NADPH + H+ | mechanistic scheme for NAD(P)H:disulfide oxidoreductases | Crithidia fasciculata | |
trypanothione + NADP+ = trypanothione disulfide + NADPH + H+ | mechanistic scheme for NAD(P)H:disulfide oxidoreductases | Trypanosoma cruzi | |
trypanothione + NADP+ = trypanothione disulfide + NADPH + H+ | mechanistic scheme for NAD(P)H:disulfide oxidoreductases | Trypanosoma congolense |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
trypanothione disulfide + NADPH | - |
Crithidia fasciculata | trypanothione + NADP+ | - |
r | |
trypanothione disulfide + NADPH | - |
Trypanosoma cruzi | trypanothione + NADP+ | - |
r | |
trypanothione disulfide + NADPH | - |
Trypanosoma congolense | trypanothione + NADP+ | - |
r |
Subunits | Comment | Organism |
---|---|---|
dimer | - |
Crithidia fasciculata |
dimer | - |
Trypanosoma cruzi |
dimer | - |
Trypanosoma congolense |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Crithidia fasciculata | |
FAD | - |
Trypanosoma cruzi | |
FAD | - |
Trypanosoma congolense | |
NADPH | - |
Crithidia fasciculata | |
NADPH | - |
Trypanosoma cruzi | |
NADPH | - |
Trypanosoma congolense |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.15 | - |
nifurtimox | - |
Trypanosoma cruzi |