Literature summary for 1.7.2.2 extracted from

Mills, P.C.; Rowley, G.; Spiro, S.; Hinton, J.C.; Richardson, D.J.
A combination of cytochrome c nitrite reductase (NrfA) and flavorubredoxin (NorV) protects Salmonella enterica serovar Typhimurium against killing by NO in anoxic environments (2008), Microbiology, 154, 1218-1228.

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Protein Variants

Protein Variants	Comment	Organism
additional information	effects of all eight possible combinations of norV, hmpA and nrfA single, double and triple mutations, overview. The norV nrfA mutant cannot grow after NO addition	Salmonella enterica

Inhibitors

Inhibitors	Comment	Organism	Structure
NO	wild-type cultures are more sensitive to the addition of a pulse of NO when grown under fermentative conditions compared with anaerobic respiratory conditions, sensitivity of different wild-type and mutant strains, overview	Salmonella enterica

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
nitrite + ferrocytochrome c + H+	Salmonella enterica	protection against NO may involve reductive detoxification in low-oxygen environments, and three enzymes, flavorubredoxin, flavohaemoglobin and cytochrome c nitrite reductase: Determination of a combined role for NorV and NrfA in NO detoxification under anaerobic conditions, overview	NH3 + H2O + ferricytochrome c	-	?

Organism

Organism	UniProt	Comment	Textmining
Salmonella enterica	-	serovar typhimurium	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
nitrite + ferrocytochrome c + H+	-	Salmonella enterica	NH3 + H2O + ferricytochrome c	-	?
nitrite + ferrocytochrome c + H+	protection against NO may involve reductive detoxification in low-oxygen environments, and three enzymes, flavorubredoxin, flavohaemoglobin and cytochrome c nitrite reductase: Determination of a combined role for NorV and NrfA in NO detoxification under anaerobic conditions, overview	Salmonella enterica	NH3 + H2O + ferricytochrome c	-	?
nitrite + reduced methyl viologen	-	Salmonella enterica	NH3 + H2O + oxidized methyl viologen	-	?

Synonyms

Synonyms	Comment	Organism
cytochrome c nitrite reductase	-	Salmonella enterica
NrfA	-	Salmonella enterica

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.5	-	assay at	Salmonella enterica

Cofactor

Cofactor	Comment	Organism	Structure
methyl viologen	artificial cofactor	Salmonella enterica

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Release 2023.1 (January 2023)