Protein Variants | Comment | Organism |
---|---|---|
additional information | when exposed to farnesol, the DELTAaifA and DELTAndeA strains have increased reactive oxygen species production while DndeB, DELTAndeA DELTAndeB, and DELTAndiA mutant strains show the same reactive oxygen species accumulation than in the absence of farnesol | Aspergillus nidulans |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
rotenone | three NADH dehydrogenases, two external rotenone-insensitive NADH:ubiquinone oxidoreductases (NDE1 and NDE2), and one internal rotenone-insensitive NADH:ubiquinone reductase (NDI1) | Aspergillus nidulans |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Aspergillus nidulans | - |
genes ndeA-B and ndiA encoding external and internal alternative NADH dehydrogenases | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
conidium | - |
Aspergillus nidulans | - |
Synonyms | Comment | Organism |
---|---|---|
alternative NADH dehydrogenase | - |
Aspergillus nidulans |
external alternative NADH dehydrogenase | - |
Aspergillus nidulans |
NdeA | - |
Aspergillus nidulans |
NdeA-B | - |
Aspergillus nidulans |
NdiA | - |
Aspergillus nidulans |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | FAD binding domain | Aspergillus nidulans | |
NADH | small NADH binding domain within a larger FAD binding domain at amino acid positions 226-334 | Aspergillus nidulans |
General Information | Comment | Organism |
---|---|---|
evolution | three NADH dehydrogenases, two external rotenone-insensitive NADH:ubiquinone oxidoreductases (NDE1 and NDE2), and one internal rotenone-insensitive NADH:ubiquinone reductase (NDI1) | Aspergillus nidulans |
additional information | NdeA shows a pyridine nucleotide-disulfide oxidoreductase domain, a small NADH binding domain within a larger FAD binding domain at amino acid positions 226-334, and an EF-hand calcium-binding domain at amino acid positions 433-468 | Aspergillus nidulans |
physiological function | external rotenone-insensitive NADH:ubiquinone oxidoreductases (NDE1 and NDE2), and one internal rotenone-insensitive NADH:ubiquinone reductase (NDI1) are involved in farnesol resistance | Aspergillus nidulans |