Cloned (Comment) | Organism |
---|---|
gene Ndi1, inducible NDI1 enzyme expression in Drosophila melanogaster mitochondria of different cells and tissues. Expression of Ndi1 in fly mitochondria leads to an increase in NADH-ubiquinone oxidoreductase activity, oxygen consumption and ATP levels. In addition, exogenous Ndi1 expression results in increased CO2 production in living flies. Targeted expression of Ndi1 in fly neurons significantly increases lifespan without compromising fertility or physical activity | Saccharomyces cerevisiae |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | Ndi1 is rotenone-insensitive | Saccharomyces cerevisiae |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Saccharomyces cerevisiae | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
gene Ndi1 | - |
Synonyms | Comment | Organism |
---|---|---|
NADH-ubiquinone oxidoreductase | - |
Saccharomyces cerevisiae |
Ndi1 | - |
Saccharomyces cerevisiae |
General Information | Comment | Organism |
---|---|---|
additional information | targeted expression of Ndi1 in fly neurons significantly increases lifespan without compromising fertility or physical activity. Expression of the yeast Ndi1 gene in Drosophila mitochondria leads to an increase in respiratory chain activity, overview | Saccharomyces cerevisiae |
physiological function | NDI1 cannot promote proton pumping | Saccharomyces cerevisiae |