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Literature summary for 1.6.5.2 extracted from

  • Siegel, D.; Shieh, B.; Yan, C.; Kepa, J.K.; Ross, D.
    Role for NAD(P)H:quinone oxidoreductase 1 and manganese-dependent superoxide dismutase in 17-(allylamino)-17-demethoxygeldanamycin-induced heat shock protein 90 inhibition in pancreatic cancer cells (2011), J. Pharmacol. Exp. Ther., 336, 874-880.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.6.5.2

Inhibitors

Inhibitors Comment Organism Structure
ES936
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NADH + H+ + 17-(allylamino)-17-demethoxygeldanamycin Homo sapiens NAD(P)H:quinone oxidoreductase 1 in pancreatic cell lines metabolizes the heat shock protein 90 inhibitor 17-(allylamino)-17-demethoxygeldanamycin to the corresponding hydroquinone ?
-
 ?
NADPH + H+ + 17-(allylamino)-17-demethoxygeldanamycin Homo sapiens NAD(P)H:quinone oxidoreductase 1 in pancreatic cell lines metabolizes the heat shock protein 90 inhibitor 17-(allylamino)-17-demethoxygeldanamycin to the corresponding hydroquinone ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
PANC-1 cell
-
 Homo sapiens
-
PANC-1 cell The stably transfected Panc-1/C5 cell line expressing NQO1 was generated from Panc-1 cells by electroporation with an elongation factor 1alpha-driven internal ribosome entry site expression vector containing full-length human NQO1-1 cDNA. Homo sapiens
-
pancreatic cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADH + H+ + 17-(allylamino)-17-demethoxygeldanamycin NAD(P)H:quinone oxidoreductase 1 in pancreatic cell lines metabolizes the heat shock protein 90 inhibitor 17-(allylamino)-17-demethoxygeldanamycin to the corresponding hydroquinone Homo sapiens ?
-
 ?
NADH + H+ + 17-(allylamino)-17-demethoxygeldanamycin NAD(P)H:quinone oxidoreductase 1 metabolizes the heat shock protein 90 inhibitor 17-(allylamino)-17-demethoxygeldanamycin to the corresponding hydroquinone Homo sapiens ?
-
 ?
NADPH + H+ + 17-(allylamino)-17-demethoxygeldanamycin NAD(P)H:quinone oxidoreductase 1 in pancreatic cell lines metabolizes the heat shock protein 90 inhibitor 17-(allylamino)-17-demethoxygeldanamycin to the corresponding hydroquinone Homo sapiens ?
-
 ?
NADPH + H+ + 17-(allylamino)-17-demethoxygeldanamycin NAD(P)H:quinone oxidoreductase 1 metabolizes the heat shock protein 90 inhibitor 17-(allylamino)-17-demethoxygeldanamycin to the corresponding hydroquinone Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
NAD(P)H:quinone oxidoreductase 1
-
 Homo sapiens
NQO1
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
27
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Homo sapiens
NADH
-
 Homo sapiens
NADPH
-
 Homo sapiens