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Literature summary for 1.6.5.2 extracted from

  • Nolan, K.A.; Scott, K.A.; Barnes, J.; Doncaster, J.; Whitehead, R.C.; Stratford, I.J.
    Pharmacological inhibitors of NAD(P)H quinone oxidoreductase, NQO1: structure/activity relationships and functional activity in tumour cells (2010), Biochem. Pharmacol., 80, 977-981.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
3,3'-methanediylbis(4-hydroxy-2H-chromen-2-one)
-
Homo sapiens
3,3'-methanediylbis(4-hydroxy-5-methoxy-2H-chromen-2-one)
-
Homo sapiens
3,3'-methanediylbis(4-hydroxy-6,7-dimethoxy-2H-chromen-2-one)
-
Homo sapiens
3,3'-methanediylbis(4-hydroxy-6,7-dimethyl-2H-chromen-2-one)
-
Homo sapiens
3,3'-methanediylbis(4-hydroxy-6-methoxy-2H-chromen-2-one)
-
Homo sapiens
3,3'-methanediylbis(4-hydroxy-7,8-dimethyl-2H-chromen-2-one)
-
Homo sapiens
3,3'-methanediylbis(4-hydroxy-7-methoxy-2H-chromen-2-one)
-
Homo sapiens
3-(3,4-dimethylbenzyl)-4-hydroxy-6,7-dimethyl-2H-chromen-2-one
-
Homo sapiens
4-hydroxy-3-(naphthalen-1-yl)cyclohepta[h]chromen-2(7H)-one
-
Homo sapiens
4-hydroxy-3-(naphthalen-2-yl)cyclohepta[h]chromen-2(7H)-one
-
Homo sapiens
4-hydroxy-3-phenylcyclohepta[h]chromen-2(7H)-one
-
Homo sapiens
4-hydroxy-6,7-dimethyl-3-(naphthalen-1-yl)-2H-chromen-2-one
-
Homo sapiens
4-hydroxy-6,7-dimethyl-3-(naphthalen-2-yl)-2H-chromen-2-one
-
Homo sapiens
4-hydroxy-6,7-dimethyl-3-phenyl-2H-chromen-2-one
-
Homo sapiens
dicoumarol
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
Homo sapiens
-
HT-29 cell
-
Homo sapiens
-
MiaPaCa-2 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
menadione + NADH
-
Homo sapiens reduced menadione + NAD+
-
?

Synonyms

Synonyms Comment Organism
DT-diaphorase
-
Homo sapiens
EC 1.6.99.2 formerly Homo sapiens
NAD(P)H quinone oxidoreductase
-
Homo sapiens
NQO1
-
Homo sapiens
quinone reductase 1
-
Homo sapiens
Vitamin K reductase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD
-
Homo sapiens
NADH
-
Homo sapiens
NADPH
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00000041
-
without bovine serum albumin, at pH 7.5, 25°C Homo sapiens 3,3'-methanediylbis(4-hydroxy-6,7-dimethyl-2H-chromen-2-one)
0.00000042
-
without bovine serum albumin, at pH 7.5, 25°C Homo sapiens 3,3'-methanediylbis(4-hydroxy-7,8-dimethyl-2H-chromen-2-one)
0.0000022
-
without bovine serum albumin, at pH 7.5, 25°C Homo sapiens 4-hydroxy-3-(naphthalen-2-yl)cyclohepta[h]chromen-2(7H)-one
0.0000025
-
without bovine serum albumin, at pH 7.5, 25°C Homo sapiens 4-hydroxy-6,7-dimethyl-3-(naphthalen-2-yl)-2H-chromen-2-one
0.0000026
-
without bovine serum albumin, at pH 7.5, 25°C Homo sapiens 3,3'-methanediylbis(4-hydroxy-2H-chromen-2-one)
0.0000028
-
without bovine serum albumin, at pH 7.5, 25°C Homo sapiens 3,3'-methanediylbis(4-hydroxy-5-methoxy-2H-chromen-2-one)
0.000006
-
without bovine serum albumin, at pH 7.5, 25°C Homo sapiens 3,3'-methanediylbis(4-hydroxy-7-methoxy-2H-chromen-2-one)
0.0000063
-
without bovine serum albumin, at pH 7.5, 25°C Homo sapiens 4-hydroxy-3-(naphthalen-1-yl)cyclohepta[h]chromen-2(7H)-one
0.0000077
-
without bovine serum albumin, at pH 7.5, 25°C Homo sapiens 4-hydroxy-6,7-dimethyl-3-(naphthalen-1-yl)-2H-chromen-2-one
0.0000099
-
without bovine serum albumin, at pH 7.5, 25°C Homo sapiens 3-(3,4-dimethylbenzyl)-4-hydroxy-6,7-dimethyl-2H-chromen-2-one
0.000011
-
without bovine serum albumin, at pH 7.5, 25°C Homo sapiens 3,3'-methanediylbis(4-hydroxy-6-methoxy-2H-chromen-2-one)
0.000035
-
without bovine serum albumin, at pH 7.5, 25°C Homo sapiens 4-hydroxy-3-phenylcyclohepta[h]chromen-2(7H)-one
0.000038
-
with 0.14% (v/v) bovine serum albumin, at pH 7.5, 25°C Homo sapiens 3,3'-methanediylbis(4-hydroxy-5-methoxy-2H-chromen-2-one)
0.000039
-
without bovine serum albumin, at pH 7.5, 25°C Homo sapiens 4-hydroxy-6,7-dimethyl-3-phenyl-2H-chromen-2-one
0.000062
-
without bovine serum albumin, at pH 7.5, 25°C Homo sapiens 3,3'-methanediylbis(4-hydroxy-6,7-dimethoxy-2H-chromen-2-one)
0.000149
-
with 0.14% (v/v) bovine serum albumin, at pH 7.5, 25°C Homo sapiens 3,3'-methanediylbis(4-hydroxy-7,8-dimethyl-2H-chromen-2-one)
0.000167
-
with 0.14% (v/v) bovine serum albumin, at pH 7.5, 25°C Homo sapiens 4-hydroxy-6,7-dimethyl-3-(naphthalen-2-yl)-2H-chromen-2-one
0.000192
-
with 0.14% (v/v) bovine serum albumin, at pH 7.5, 25°C Homo sapiens 3-(3,4-dimethylbenzyl)-4-hydroxy-6,7-dimethyl-2H-chromen-2-one
0.000225
-
with 0.14% (v/v) bovine serum albumin, at pH 7.5, 25°C Homo sapiens 4-hydroxy-3-(naphthalen-2-yl)cyclohepta[h]chromen-2(7H)-one
0.000233
-
with 0.14% (v/v) bovine serum albumin, at pH 7.5, 25°C Homo sapiens 3,3'-methanediylbis(4-hydroxy-6,7-dimethyl-2H-chromen-2-one)
0.000404
-
with 0.14% (v/v) bovine serum albumin, at pH 7.5, 25°C Homo sapiens 3,3'-methanediylbis(4-hydroxy-2H-chromen-2-one)
0.00045
-
with 0.14% (v/v) bovine serum albumin, at pH 7.5, 25°C Homo sapiens 4-hydroxy-3-(naphthalen-1-yl)cyclohepta[h]chromen-2(7H)-one
0.00066
-
with 0.14% (v/v) bovine serum albumin, at pH 7.5, 25°C Homo sapiens 4-hydroxy-6,7-dimethyl-3-phenyl-2H-chromen-2-one
0.00079
-
with 0.14% (v/v) bovine serum albumin, at pH 7.5, 25°C Homo sapiens 3,3'-methanediylbis(4-hydroxy-7-methoxy-2H-chromen-2-one)
0.00088
-
with 0.14% (v/v) bovine serum albumin, at pH 7.5, 25°C Homo sapiens 4-hydroxy-3-phenylcyclohepta[h]chromen-2(7H)-one
0.001095
-
with 0.14% (v/v) bovine serum albumin, at pH 7.5, 25°C Homo sapiens 4-hydroxy-6,7-dimethyl-3-(naphthalen-1-yl)-2H-chromen-2-one
0.001497
-
with 0.14% (v/v) bovine serum albumin, at pH 7.5, 25°C Homo sapiens 3,3'-methanediylbis(4-hydroxy-6,7-dimethoxy-2H-chromen-2-one)
0.0033
-
with 0.14% (v/v) bovine serum albumin, at pH 7.5, 25°C Homo sapiens 3,3'-methanediylbis(4-hydroxy-6-methoxy-2H-chromen-2-one)