Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.6.5.2 extracted from

  • Augustine, L.M.; Fisher, C.D.; Lickteig, A.J.; Aleksunes, L.M.; Slitt, A.L.; Cherrington, N.J.
    Gender divergent expression of Nqo1 in Sprague Dawley and August Copenhagen x Irish rats (2008), J. Biochem. Mol. Toxicol., 22, 93-100.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
butylated hydroxyanisole inducer Rattus norvegicus
oltipraz inducer Rattus norvegicus

Application

Application Comment Organism
medicine strain difference where Sprague Dawley rats possess a sex-dependent expression and activity of Nqo1 and August Copenhagen x Irish rats exhibit no sexual dimorphism may provide an important tool when using these rat models for oxidative stress and cancer studies Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Rattus norvegicus 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
32000
-
Western blot analysis Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
Sprague Dawley and August Copenhagen x Irish strains
-

Source Tissue

Source Tissue Comment Organism Textmining
liver in the Sprague Dawley strain, gender dimorphic expression of Nqo1 with female mRNA, protein, and activity levels being significantly higher than in males. Minimal differences in Nqo1 mRNA, protein, and activity levels between August Copenhagen x Irish males and females Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADPH + H+ + oxidized 2,6-dichlorophenolindophenol
-
Rattus norvegicus NADP+ + reduced 2,6-dichlorophenolindophenol
-
?

Synonyms

Synonyms Comment Organism
NAD(P)H:quinone oxidoreducatase 1
-
Rattus norvegicus
NQO1
-
Rattus norvegicus