Literature summary for 1.6.5.2 extracted from

Joung, E.J.; Li, M.H.; Lee, H.G.; Somparn, N.; Jung, Y.S.; Na, H.K.; Kim, S.H.; Cha, Y.N.; Surh, Y.J.
Capsaicin induces heme oxygenase-1 expression in HepG2 cells via activation of PI3K-Nrf2 signaling: NAD(P)H:quinone oxidoreductase as a potential target (2007), Antioxid. Redox Signal., 9, 2087-2098.

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Inhibitors

Inhibitors	Comment	Organism	Structure
capsaicin	activity is decreased after the treatment with capsaicin or dicoumarol. Quinone metabolites or other reactive forms of capsaicin may bind covalently to NQO1 and thereby inhibit its activity, leading to production of reactive oxygen species; suppresses NQO1 expression and activity. Quinone metabolites or other reactive forms of capsaicin may bind covalently to NQO1 and thereby inhibit its activity, leading to production of reactive oxygen species	Homo sapiens
dicoumarol	-	Homo sapiens
dicumarol	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Hep-G2 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
NAD(P)H:quinone oxidoreductase	-	Homo sapiens
NQO1	-	Homo sapiens

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Release 2023.1 (January 2023)