Literature summary for 1.6.5.2 extracted from

Lee, Y.Y.; Westphal, A.H.; de Haan, L.H.; Aarts, J.M.; Rietjens, I.M.; van Berkel, W.J.
Human NAD(P)H:quinone oxidoreductase inhibition by flavonoids in living cells (2005), Free Radic. Biol. Med., 39, 257-265.

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Application

Application	Comment	Organism
analysis	method to measure enzyme inhibition in intact cells based on the resorufin reductase activity of enzyme. Values for 50% inhibition of enzyme by several reported in vivo inhibitors is at least three orders of magnitude higher for intact cells than for cell lysates	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
7,8-dihydroxyflavone	-	Homo sapiens
7-hydroxyflavone	-	Homo sapiens
chrysin	-	Homo sapiens
dicoumarol	-	Homo sapiens
isorhamnetin	-	Homo sapiens
quercetin	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	recombinant enzyme expressed in Chinese hamster ovary cells	-

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0005	-	dicoumarol	value for lysed cells	Homo sapiens
0.016	-	7,8-dihydroxyflavone	value for lysed cells	Homo sapiens
0.017	-	chrysin	value for lysed cells	Homo sapiens
0.309	-	7-hydroxyflavone	value for lysed cells	Homo sapiens
1.03	-	isorhamnetin	value for lysed cells	Homo sapiens
6.19	-	quercetin	value for lysed cells	Homo sapiens

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Release 2023.1 (January 2023)