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Literature summary for 1.6.5.2 extracted from

  • Vella, F.; Ferry, G.; Delagrange, P.; Boutin, J.A.
    NRH:quinone reductase 2: an enzyme of surprises and mysteries (2005), Biochem. Pharmacol., 71, 1-12.
    View publication on PubMed
Search for more literature for 1.6.5.2

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD(P)H + H+ + a quinone Homo sapiens the enzyme catalyzes a detoxification process. QR1 gene expression is induced in response to xenobiotics, oxidants, heavy metals, UV light, and ionisation radiation. The enzyme is part of an electrophilic-induced and/or oxidative stress-induced cellular defense mechanism that includes the induction of more than two dozen defensive genes NAD(P)+ + a hydroquinone
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Organism

Organism UniProt Comment Textmining
Homo sapiens P15559 comparison with quinone reductase 2
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Source Tissue

Source Tissue Comment Organism Textmining
liver traces Homo sapiens
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additional information no expression in erythrocytes Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD(P)H + H+ + a quinone the enzyme catalyzes a detoxification process. QR1 gene expression is induced in response to xenobiotics, oxidants, heavy metals, UV light, and ionisation radiation. The enzyme is part of an electrophilic-induced and/or oxidative stress-induced cellular defense mechanism that includes the induction of more than two dozen defensive genes Homo sapiens NAD(P)+ + a hydroquinone
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 ?

Synonyms

Synonyms Comment Organism
NRH:quinone reductase 1
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 Homo sapiens
QR1
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 Homo sapiens
quinone reductase 1
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 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD(P)H Gly149, Tyr155 and His161 are directly involved in the electron transfer from NAD(P)H to FAD and from FADH2 to the quinone Homo sapiens