Literature summary for 1.6.5.2 extracted from

Swann, E.; Barraja, P.; Oberlander, A.M.; Gardipee, W.T.; Hudnott, A.R.; Beall, H.D.; Moody, C.J.
Indolequinone antitumor agents: correlation between quinone structure and rate of metabolism by recombinant human NAD(P)H:quinone oxidoreductase. Part 2 (2001), J. Med. Chem., 44, 3311-3319.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
indolequinones + NAD(P)H	compounds with electron-withdrawing groups at the indole 3-position are among the best substrates, groups larger than methyl at N-1 are tolerated, compounds with a leaving group at the 3-indolyl methyl position inactivate the enzyme	Homo sapiens	indolehydroquinones + NAD(P)+	-	?

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Release 2023.1 (January 2023)