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Literature summary for 1.6.5.2 extracted from

  • Cloete, F.; Viljoen, C.C.; Scott, W.E.; Oosthuizen, M.M.J.
    A steady-state kinetic investigation of the mechanism of action of NAD(P)H dehydrogenase of the cyanobacterium, Microcystis aeruginosa (1986), Biochim. Biophys. Acta, 870, 279-291.
No PubMed abstract available
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Inhibitors

Inhibitors Comment Organism Structure
1,4-Naphthohydroquinone competitive vs. 1,4-naphthohydroquinone, noncompetitive vs. NADPH Microcystis aeruginosa
NADP+ noncompetitive vs. NADPH Microcystis aeruginosa

Organism

Organism UniProt Comment Textmining
Microcystis aeruginosa
-
-
-

Reaction

Reaction Comment Organism Reaction ID
NAD(P)H + H+ + a quinone = NAD(P)+ + a hydroquinone ordered bi-bi mechanism Microcystis aeruginosa
a

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0075
-
 1,4-Naphthohydroquinone vs. 1,4-naphthoquinone, value derived from from intercept Microcystis aeruginosa
0.008
-
 1,4-Naphthohydroquinone vs. NADPH, value derived from from slope Microcystis aeruginosa
0.039
-
 NADP+ vs. NADPH, value derived from from intercept Microcystis aeruginosa
0.058
-
 NADP+ vs. NADPH, value derived from from slope Microcystis aeruginosa
0.077
-
 NADP+ vs. 1,4-naphthoquinone, value derived from from slope Microcystis aeruginosa
0.14
-
 NADP+ vs. 1,4-naphthoquinone, value derived from intercept Microcystis aeruginosa