Literature summary for 1.6.3.5 extracted from

Zhou, M.; Liang, T.; Wang, Y.; Jin, D.; Wang, J.; Jia, L.; Zhang, S.
Expression and tissue localization of renalase, a novel soluble FAD-dependent protein, in reproductive/steroidogenic systems (2013), Mol. Biol. Rep., 40, 3987-3994.

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	A7RDN6	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
adrenal gland	substantial expression cortex of adrenal gland	Mus musculus	-
granulosa cell	substantial expression in granulosa	Mus musculus	-
additional information	renalase is predominantly expressed in reproductive/steroidogenic systems, with particularly substantial expression in oocytes, granulosa, interstitial and luteal cells of ovary, spermatogenic cells of testis, and cortex of adrenal gland	Mus musculus	-
oocyte	substantial expression in oocytes	Mus musculus	-
ovary	substantial expression in interstitial and luteal cells of ovary. Expression increases in testes and ovaries as mice develop and is further enhanced in the ovaries of pregnant mice	Mus musculus	-
testis	substantial expression spermatogenic cells of testis. Expression increases in testes and ovaries as mice develop	Mus musculus	-

Expression

Organism	Comment	Expression
Mus musculus	gonadotropin-releasing hormone antagonist, cetrorelix, represses renalase expression in mice ovaries and testes	down
Mus musculus	knockout of leptin, an effector and modulator of steroid hormones and reproduction, causes a dramatic increase of renalase expression in mice testes	up

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Release 2023.1 (January 2023)