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Literature summary for 1.6.3.5 extracted from

  • Beaupre, B.A.; Carmichael, B.R.; Hoag, M.R.; Shah, D.D.; Moran, G.R.
    Renalase is an alpha-NAD(P)H oxidase/anomerase (2013), J. Am. Chem. Soc., 135, 13980-13987.
    View publication on PubMed
Search for more literature for 1.6.3.5

Cloned(Commentary)

Cloned (Comment) Organism
N-terminally His-tagged renalase isoform 1 is expressed in Escherichia coli. Heterologous expression of renalase in Escherichia coli results in significant inclusion body accumulation at all temperatures tested Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
alpha-NAD(P)H + H+ + O2 Homo sapiens renalase is a protein hormone secreted into the blood by the kidney that is reported to lower blood pressure and slow heart rate beta-NAD(P)+ + H2O2
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q5VYX0
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-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Storage Stability

Storage Stability Organism
-80°C, stable in PBS buffer (10 mM Na2HPO4, 2 mM KH2PO4, 2.7 mM KCl, 137 mM NaCl, pH 7.4), can be stored indefinitely Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-NAD(P)H + H+ + O2 renalase is a protein hormone secreted into the blood by the kidney that is reported to lower blood pressure and slow heart rate Homo sapiens beta-NAD(P)+ + H2O2
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 ?
alpha-NAD(P)H + H+ + O2 the substrate alpha-dihydropyridyl ring is oxidized by transferring two electrons to the flavin cofactor and the configuration of the ribose C1 is converted from alpha to beta. The reduced FAD cofactor then reoxidizes by reacting with dioxygen to yield hydrogen peroxide Homo sapiens beta-NAD(P)+ + H2O2
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 ?

Synonyms

Synonyms Comment Organism
alphaNAD(P)H oxidase/anomerase
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 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD flavoprotein. The substrate alpha-dihydropyridyl ring is oxidized by transferring two electrons to the flavin cofactor and the configuration of the ribose C1 is converted from alpha to beta. The reduced FAD cofactor then reoxidizes by reacting with dioxygen to yield hydrogen peroxide Homo sapiens

General Information

General Information Comment Organism
physiological function renalase is a protein hormone secreted into the blood by the kidney that is reported to lower blood pressure Homo sapiens