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Literature summary for 1.6.3.1 extracted from

  • Cooney, S.J.; Zhao, Y.; Byrnes, K.R.
    Characterization of the expression and inflammatory activity of NADPH oxidase after spinal cord injury (2014), Free Radic. Res., 48, 929-939 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.6.3.1

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NADPH + H+ + O2 Rattus norvegicus
-
 NADP+ + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte isoforms NOX2 and NOX4 Rattus norvegicus
-
macrophage isoforms NOX2 and NOX4 Rattus norvegicus
-
microglial cell isoforms NOX2 and NOX4 Rattus norvegicus
-
neuron isoforms NOX2 and NOX3 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADPH + H+ + O2
-
 Rattus norvegicus NADP+ + H2O2
-
 ?

Synonyms

Synonyms Comment Organism
NADPH oxidase
-
 Rattus norvegicus
Nox2 isoform Rattus norvegicus
NOX3 isoform Rattus norvegicus
Nox4 isoform Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus the enzyme is up-regulated after spinal cord injury up

General Information

General Information Comment Organism
physiological function the enzyme plays a significant role in promoting post-injury inflammation after spinal cord injury Rattus norvegicus