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Literature summary for 1.6.3.1 extracted from

  • Montero-Barrientos, M.; Hermosa, R.; Cardoza, R.E.; Gutierrez, S.; Monte, E.
    Functional analysis of the Trichoderma harzianum nox1 gene, encoding an NADPH oxidase, relates production of reactive oxygen species to specific biocontrol activity against Pythium ultimum (2011), Appl. Environ. Microbiol., 77, 3009-3016.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene nox1, DNA and amino acid sequence determination and analysis, quantitative real-time PCR expression analysis, recombinant expression in wild-type Trichoderma harzianum leading to increased levels of Nox1, which is accompanied by an increase in reactive oxgen species production during their direct confrontation with Pythium ultimum. The transformants display an increased hydrolytic pattern Trichoderma harzianum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NADPH + H+ + O2 Trichoderma harzianum
-
NADP+ + H2O2
-
?
NADPH + H+ + O2 Trichoderma harzianum T34
-
NADP+ + H2O2
-
?

Organism

Organism UniProt Comment Textmining
Trichoderma harzianum F4ZCJ9 gene nox1
-
Trichoderma harzianum T34 F4ZCJ9 gene nox1
-

Source Tissue

Source Tissue Comment Organism Textmining
mycelium
-
Trichoderma harzianum
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADPH + H+ + O2
-
Trichoderma harzianum NADP+ + H2O2
-
?
NADPH + H+ + O2
-
Trichoderma harzianum T34 NADP+ + H2O2
-
?

Synonyms

Synonyms Comment Organism
NOX1
-
Trichoderma harzianum

Cofactor

Cofactor Comment Organism Structure
FAD Nox1 protein reveals the presence of six transmembrane domains and one FAD/NADPH binding cytosolic domain Trichoderma harzianum
NADPH Nox1 protein reveals the presence of six transmembrane domains and one FAD/NADPH binding cytosolic domain Trichoderma harzianum

General Information

General Information Comment Organism
physiological function Nox1 relates production of reactive oxygen species to specific biocontrol activity against Pythium ultimum, but not Botrytis cinerea or Rhizoctonia solani Trichoderma harzianum