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Literature summary for 1.6.3.1 extracted from

  • Kahles, T.; Luedike, P.; Endres, M.; Galla, H.J.; Steinmetz, H.; Busse, R.; Neumann-Haefelin, T.; Brandes, R.P.
    NADPH oxidase plays a central role in blood-brain barrier damage in experimental stroke (2007), Stroke, 38, 3000-3006.
    View publication on PubMed

Application

Application Comment Organism
medicine in brain capillary endothelial cells, hypoxia/reoxygenation induces translocation of the NAD(P)H oxidase activator Rac-1 to the membrane. Inhibition of Rac-1 prevents the ischemia/reperfusion-induced blood-brain barrier disruption. Activation of NAD(P)H oxidase promotes cerebral reactive oxygen species formation, which then leads to Rho kinase-mediated endothelial cell contraction and disruption of the blood-brain barrier Sus scrofa
medicine inhibition of NAD(P)H oxidase by apocynin in ischemia-induced mice prevents blood-brain barrier damage in the ischemic hemisphere I after reperfusion. In mice deficient in subunit gp91phox, middle cerebral artery occlusion-induced blood-brain barrier disruption and lesion volume in ischemia-induced animals are largely attenuated. Activation of NAD(P)H oxidase promotes cerebral reactive oxygen species formation, which then leads to Rho kinase-mediated endothelial cell contraction and disruption of the blood-brain barrier Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information in mice deficient in subunit gp91phox, middle cerebral artery occlusion-induced blood-brain barrier disruption and lesion volume in ischemia-induced animals are largely attenuated Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
apocynin inhibition of NAD(P)H oxidase by apocynin in ischemia-induced mice prevents blood-brain barrier damage in the ischemic hemisphere I after reperfusion Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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Sus scrofa
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Source Tissue

Source Tissue Comment Organism Textmining
brain
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Mus musculus
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brain
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Sus scrofa
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