Application | Comment | Organism |
---|---|---|
medicine | in brain capillary endothelial cells, hypoxia/reoxygenation induces translocation of the NAD(P)H oxidase activator Rac-1 to the membrane. Inhibition of Rac-1 prevents the ischemia/reperfusion-induced blood-brain barrier disruption. Activation of NAD(P)H oxidase promotes cerebral reactive oxygen species formation, which then leads to Rho kinase-mediated endothelial cell contraction and disruption of the blood-brain barrier | Sus scrofa |
medicine | inhibition of NAD(P)H oxidase by apocynin in ischemia-induced mice prevents blood-brain barrier damage in the ischemic hemisphere I after reperfusion. In mice deficient in subunit gp91phox, middle cerebral artery occlusion-induced blood-brain barrier disruption and lesion volume in ischemia-induced animals are largely attenuated. Activation of NAD(P)H oxidase promotes cerebral reactive oxygen species formation, which then leads to Rho kinase-mediated endothelial cell contraction and disruption of the blood-brain barrier | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | in mice deficient in subunit gp91phox, middle cerebral artery occlusion-induced blood-brain barrier disruption and lesion volume in ischemia-induced animals are largely attenuated | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
apocynin | inhibition of NAD(P)H oxidase by apocynin in ischemia-induced mice prevents blood-brain barrier damage in the ischemic hemisphere I after reperfusion | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Sus scrofa | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
brain | - |
Sus scrofa | - |