Literature summary for 1.6.3.1 extracted from

Steinkamp-Fenske, K.; Bollinger, L.; Xu, H.; Yao, Y.; Horke, S.; Foerstermann, U.; Li, H.
Reciprocal regulation of endothelial nitric-oxide synthase and NADPH oxidase by betulinic acid in human endothelial cells (2007), J. Pharmacol. Exp. Ther., 322, 836-842.

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Inhibitors

Inhibitors	Comment	Organism	Structure
betulinic acid	attenuates the expression of NAD(P)H oxidase subunits Nox4 and p22phox, thereby reducing oxidative stress and improving endothelial nitric oxide synthase function. Treated cells show in increased production of bioactive nitric oxide	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
EAhy 926 cell	HUVEC-derived cell	Homo sapiens	-
HUVEC cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)