Literature summary for 1.6.3.1 extracted from

Teixeira, C.E.; Priviero, F.B.; Webb, R.C.
Effects of 5-cyclopropyl-2-[1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridine-3-yl]pyrimidin-4-ylamine (BAY 41-2272) on smooth muscle tone, soluble guanylyl cyclase activity, and NADPH oxidase activity/expression in corpus cavernosum from wild-type, neuronal (2007), J. Pharmacol. Exp. Ther., 322, 1093-1102.

Search for more literature for 1.6.3.1

Activating Compound

Activating Compound	Comment	Organism	Structure
11alpha,9alpha-epoxymethanoprostaglandin F 2alpha	induces the expression of subunits p22phox and gp91phox	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
5-cyclopropyl-2-[1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridine-3-yl]pyrimidin-4-ylamine	i.e. BAY 41-2272, inhibits the induction of the expression of subunits p22phox and gp91phox by 11alpha,9alpha-epoxymethanoprostaglandin F 2alpha. Enhances nitric oxide-induced relaxations in a concentration-dependent manner	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
corpus cavernosum	-	Mus musculus	-
penis	-	Mus musculus	-

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)