Literature summary for 1.6.3.1 extracted from

Schaeppi, M.; Deffert, C.; Fiette, L.; Gavazzi, G.; Herrmann, F.; Belli, D.; Krause, K.H.
Branched fungal beta-glucan causes hyperinflammation and necrosis in phagocyte NADPH oxidase-deficient mice (2008), J. Pathol., 214, 434-444.

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Application

Application	Comment	Organism
medicine	induction of sterile hyperinflammation by injection of fungal cell wall preparations in chronic granulomatous disease mouse model. Preparations from Aspergillus fumigatus, Candida albicans, or Saccharomyces cerevisiae cause prolonged and severe skin inflammation, but not preparations from bacteria such as Staphylococcus aureus, Pseudomonas aerginosa, or Escherichia coli. Components most responsible for the inflammatory effect are branched fungal beta-glucans	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	NOX2-deficient mice serve as chronic granulomatous disease mouse model	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	phagocyte NADPH oxidase-deficient mice	-

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Release 2023.1 (January 2023)