Literature summary for 1.6.3.1 extracted from

Roepstorff, K.; Rasmussen, I.; Sawada, M.; Cudre-Maroux, C.; Salmon, P.; Bokoch, G.; van Deurs, B.; Vilhardt, F.
Stimulus-dependent regulation of the phagocyte NADPH oxidase by a VAV1, Rac1, and PAK1 signaling axis (2008), J. Biol. Chem., 283, 7983-7993.

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Activating Compound

Activating Compound	Comment	Organism	Structure
N-formyl-L-methionyl-L-leucyl-L-phenylalanine	stimulation. Conditional expression of p21-activated kinase-1 PAK1 dominant-positive mutants enhances, whereas dominant-negative mutants inhibit, NADPH oxidase-mediated superoxide generation stimulated by N-formyl-L-methionyl-L-leucyl-L-phenylalanine. Both Rac1 and the GTP exchange factor VAV1 are required as upstream signaling proteins, and the effect of p21-activated kinase-1 PAK1 on the respiratory burst is mediated through phosphorylation of subunit p47phox	Mus musculus
phorbol 12-myristate 13-acetate	stimulation. Conditional expression of p21-activated kinase-1 PAK1 dominant-positive mutants enhances, whereas dominant-negative mutants inhibit, NADPH oxidase-mediated superoxide generation stimulated by N-formyl-L-methionyl-L-leucyl-L-phenylalanine	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
S303D/S304D/S320D	mutant in subunit p47phox,which mimics phosphorylation by p21-activated kinase-1 PAK1. Expression of mutant induces basal superoxide generation in vivo	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	Conditional expression of p21-activated kinase-1 PAK1 dominant-positive mutants enhances NADPH oxidase-mediated superoxide generation stimulated by formyl-methionyl-leucylphenylalanine. Stimulation by p21-activated kinase-1 PAK1 is mediated through phosphorylation of subunit p47phox	Mus musculus

Source Tissue

Source Tissue	Comment	Organism	Textmining
Ra-2 cell	microglial cell line	Mus musculus	-

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Release 2023.1 (January 2023)