Literature summary for 1.6.3.1 extracted from

Wei, Y.; Whaley-Connell, A.T.; Chen, K.; Habibi, J.; Uptergrove, G.M.; Clark, S.E.; Stump, C.S.; Ferrario, C.M.; Sowers, J.R.
NADPH oxidase contributes to vascular inflammation, insulin resistance, and remodeling in the transgenic (mRen2) rat (2007), Hypertension, 50, 384-391.

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Application

Application	Comment	Organism
medicine	aortas of transgenic rats harboring the mouse renin transgene exhibit greater NADPH oxidase activity, reactive oxygen species levels, C-reactive protein, tumor necrosis factor-alpha expression, apoptosis, and wall thickness, which are significantly attenuated by in vivo treatment with angiotensin type 1 receptor blockade by valsartan or the superoxide dismutase/catalase mimetic tempol	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	transgenic rats harboring the mouse renin transgene and exhibiting elevated tissue angiotensin II levels	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
aorta	aortas of transgenic rats harboring the mouse renin transgene exhibit greater NADPH oxidase activity, reactive oxygen species levels, C-reactive protein, tumor necrosis factor-alpha expression, apoptosis, and wall thickness, which are significantly attenuated by in vivo treatment with angiotensin type 1 receptor blockade by valsartan or the superoxide dismutase/catalase mimetic tempol	Rattus norvegicus	-

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Release 2023.1 (January 2023)