Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | knockout of adenosine A2A receptor significantly decreases NADPH-dependent superoxide anion production in mouse hearts compared to age-matched wild-type controls, accompanied by a significant decrease in catalytic subunit Nox2 protein expression, and down-regulation of ERK1/2, p38MAPK, and JNK phosphorylation. In wild-type mice, intraperitoneal injection of the selective adenosine A2A receptor antagonist SCH58261 inhibits phosphorylation of regulatory subunit p47phox, which is accompanied by a down-regulated cardiac reactive oxygen species production, and decreased JNK and ERK1/2 activation | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | adenosine A2A receptor regulates subunit p47phox phosphorylation and cardiac reactive oxygen species production by NADPH oxidase through MAPK signaling | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Mus musculus | - |