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Literature summary for 1.6.3.1 extracted from

  • Cano-Dominguez, N.; Alvarez-Delfin, K.; Hansberg, W.; Aguirre, J.
    NADPH oxidases NOX-1 and NOX-2 require the regulatory subunit NOR-1 to control cell differentiation and growth in Neurospora crassa (2008), Eukaryot. Cell, 7, 1352-1361.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information isoform NOX-1 elimination by gene replacement results in complete female sterility, decreased asexual development, and reduction of hyphal growth. The lack of isoform NOX-2 does not affect any of these processes but leads instead to the production of sexual spores that fail to germinate, even in the presence of exogenous oxidants. The elimination of NOR-1, an ortholog of the mammalian Nox2 regulatory subunit gp67phox, also causes female sterility, the production of unviable sexual spores, and a decrease in asexual development and hyphal growth Neurospora crassa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Neurospora crassa isoform NOX-1 is required for sexual and asexual development, and normal hyphal growth, while isoform NOX-2 is specifically involved in sexual spore function. Regulatory subunit NOR-1 is required for NOX-1 and NOX-2 functions at different developmental stages ?
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Organism

Organism UniProt Comment Textmining
Neurospora crassa
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information isoform NOX-1 is required for sexual and asexual development, and normal hyphal growth, while isoform NOX-2 is specifically involved in sexual spore function. Regulatory subunit NOR-1 is required for NOX-1 and NOX-2 functions at different developmental stages Neurospora crassa ?
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?