Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Urea | increase of activity by 250% in presence of 1 M urea with no apparent perturbation in enzyme structure. Presence of urea prohibits the closing of the active site thus allowing the substrate to bind | Thermus thermophilus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Thermus thermophilus | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
NAD(P)H + H+ + O2 = NAD(P)+ + H2O2 | in stable conformation, the active site adopts a closed conformation not allowing the substrate to bind. In presence of urea, an open conformation of the active site with 0.9 nm distance between the indole ring of W47 and the isoalloxazine ring of FMN412 is favored | Thermus thermophilus |