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Literature summary for 1.6.3.1 extracted from

  • Jekabsone, A.; Mander, P.K.; Tickler, A.; Sharpe, M.; Brown, G.C.
    Fibrillar beta-amyloid peptide Abeta1-40 activates microglial proliferation via stimulating TNF-alpha release and H2O2 derived from NADPH oxidase: a cell culture study (2006), J. Neuroinflammation, 3, 24.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine proliferation of microglial cells induced by fibrillar beta-amyloid peptide Abeta1-40 is mediated both by microglial release of TNF-alpha and by production of hydrogen peroxide by enzyme. TNF-alpha and enzyme, and its products, are potential targets to prevent Abeta-induced inflammatory neurodegeneration Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Source Tissue

Source Tissue Comment Organism Textmining
astrocyte primary culture. Proliferation induced by fibrillar beta-amyloid peptide Abeta1-40 is mediated both by microglial release of TNF-alpha and by production of hydrogen peroxide by enzyme Rattus norvegicus
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glial cell primary culture. Proliferation induced by fibrillar beta-amyloid peptide Abeta1-40 is mediated both by microglial release of TNF-alpha and by production of hydrogen peroxide by enzyme Rattus norvegicus
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