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Literature summary for 1.6.2.4 extracted from
- Altered heme catabolism by heme oxygenase-1 caused by mutations in human NADPH cytochrome P450 reductase (2010), Biochem. Biophys. Res. Commun., 400, 374-378.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli BL21(DE3) cells | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| A287P | the POR mutant is associated with 75-80% of normal heme oxygenase-1 activity | Homo sapiens |
| A457H | the POR mutant is associated with total loss of heme oxygenase-1 activity | Homo sapiens |
| A503V | the POR mutant is associated with close to wild type activity of heme oxygenase-1 | Homo sapiens |
| C569Y | the POR mutant is associated with 75-80% of normal heme oxygenase-1 activity | Homo sapiens |
| G413S | the POR mutant is associated with close to wild type activity of heme oxygenase-1 | Homo sapiens |
| G504R | the POR mutant is associated with close to wild type activity of heme oxygenase-1 | Homo sapiens |
| P228L | the POR mutant is associated with close to wild type activity of heme oxygenase-1 | Homo sapiens |
| R316W | the POR mutant is associated with close to wild type activity of heme oxygenase-1 | Homo sapiens |
| R616X | the POR mutant is associated with total loss of heme oxygenase-1 activity | Homo sapiens |
| V492E | the POR mutant is associated with total loss of heme oxygenase-1 activity | Homo sapiens |
| V608F | the POR mutant is associated with 75-80% of normal heme oxygenase-1 activity | Homo sapiens |
| Y181D | the POR mutant is associated with total loss of heme oxygenase-1 activity | Homo sapiens |
| Y459H | the POR mutant is associated with total loss of heme oxygenase-1 activity | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Homo sapiens | 16020 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2 ferricytochrome P450 + NADPH | Homo sapiens | - |
2 ferrocytochrome P450 + NADP+ + H+ | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| Q-Sepharose column chromatography and Superdex 200 gel filtration | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2 ferricytochrome P450 + NADPH | - |
Homo sapiens | 2 ferrocytochrome P450 + NADP+ + H+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CPR | - |
Homo sapiens |
| NADPH P450 reductase | - |
Homo sapiens |
| POR | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | - |
Homo sapiens | |
| FMN | - |
Homo sapiens | |
| NADPH | - |
Homo sapiens | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | mutations in POR may reduce heme oxygenase-1 activity, potentially influencing heme catabolism in individuals carrying mutant POR alleles | Homo sapiens |
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Release 2023.1 (January 2023)
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