Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Trypanosoma cruzi |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
diphenyleneiodonium | 0.03 mM, 62% inhibition; 0.03 mM, 64% inhibition; 0.03 mM, 76% inhibition | Trypanosoma cruzi |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00577 | - |
NADPH | pH 7.7, 30°C | Trypanosoma cruzi | |
0.0098 | - |
ferricytochrome c | pH 7.7, 30°C | Trypanosoma cruzi | |
0.017 | - |
ferricytochrome c | pH 7.7, 30°C | Trypanosoma cruzi | |
0.018 | - |
ferricytochrome c | pH 7.7, 30°C | Trypanosoma cruzi | |
0.0511 | - |
NADPH | pH 7.7, 30°C | Trypanosoma cruzi | |
0.05488 | - |
NADPH | pH 7.7, 30°C | Trypanosoma cruzi |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
68600 | - |
x * 68600, calculated from sequence | Trypanosoma cruzi |
71300 | - |
x * 71300, calculated from sequence | Trypanosoma cruzi |
78400 | - |
x * 78400, calculated from sequence | Trypanosoma cruzi |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma cruzi | Q003G7 | - |
- |
Trypanosoma cruzi | Q003G8 | - |
- |
Trypanosoma cruzi | Q0MRD4 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Trypanosoma cruzi |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
amastigote | - |
Trypanosoma cruzi | - |
epimastigote | - |
Trypanosoma cruzi | - |
epimastigote | overexpression of TcCPR-B in Trypanosoma cruzi epimastigotes increases its resistance to the typical chemotherapeutic agents Nifurtimox and Benznidazole | Trypanosoma cruzi | - |
additional information | presence in every Trypanosoma cruzi developmental stage | Trypanosoma cruzi | - |
trypomastigote | - |
Trypanosoma cruzi | - |
trypomastigote | strongly expressed | Trypanosoma cruzi | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 ferricytochrome c + NADPH | - |
Trypanosoma cruzi | 2 ferrocytochrome c + NADP+ + H+ | - |
? | |
additional information | menadione or adrenaline are not reduced | Trypanosoma cruzi | ? | - |
? | |
additional information | menadione or adrenaline ate not reduced | Trypanosoma cruzi | ? | - |
? | |
NADPH + H+ + oxidized 2,6-dichlorophenolindophenol | - |
Trypanosoma cruzi | NADP+ + reduced 2,6-dichlorophenolindophenol | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 68600, calculated from sequence | Trypanosoma cruzi |
? | x * 71300, calculated from sequence | Trypanosoma cruzi |
? | x * 78400, calculated from sequence | Trypanosoma cruzi |
Synonyms | Comment | Organism |
---|---|---|
CPR | - |
Trypanosoma cruzi |
NADPH-cytochrome P450 reductase | - |
Trypanosoma cruzi |
TcCPR-A | - |
Trypanosoma cruzi |
TcCPR-B | - |
Trypanosoma cruzi |
TcCPR-C | - |
Trypanosoma cruzi |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Trypanosoma cruzi | |
ferricytochrome c | - |
Trypanosoma cruzi | |
FMN | - |
Trypanosoma cruzi | |
NADPH | - |
Trypanosoma cruzi |