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Literature summary for 1.6.2.4 extracted from

  • Bozcaarmutlu, A.; Arinc, E.
    Effect of mercury, cadmium, nickel, chromium and zinc on kinetic properties of NADPH-cytochrome P450 reductase purified from leaping mullet (Liza saliens) (2006), Toxicol. in Vitro, 21, 408-416.
    View publication on PubMed
Search for more literature for 1.6.2.4

Inhibitors

Inhibitors Comment Organism Structure
Cd2+ 0.05 mM, 66% inhibition. IC50: 0.024 mM, noncompetitive inhibition; 0.05 mM, 66% inhibition, noncompetitive Chelon saliens
Cr3+ 0.05 mM,65% inhibition. IC50: 0.033 mM, noncompetitive inhibition; 0.05 mM, 65% inhibition, noncompetitive Chelon saliens
Hg2+ 0.05 mM, complete inhibition. IC50: 0.00007 mM, noncompetitive inhibition; 0.05 mM, complete inhibition, noncompetitive Chelon saliens
additional information no inhibition by 0.05 mM Zn2+ Chelon saliens
Ni2+ 0.05 mM, 37% inhibition. IC50: 0.143 mM, noncompetitive inhibition; 0.05 mM, 37% inhibition, noncompetitive Chelon saliens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Chelon saliens
-
-

Organism

Organism UniProt Comment Textmining
Chelon saliens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Chelon saliens

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Chelon saliens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 ferricytochrome c + NADPH
-
 Chelon saliens 2 ferrocytochrome c + NADP+ + H+
-
 ?

Synonyms

Synonyms Comment Organism
NADPH-cytochrome P450 reductase
-
 Chelon saliens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Chelon saliens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000048
-
 Hg2+
-
 Chelon saliens
0.000048
-
 Hg2+ pH 7.7, 24°C Chelon saliens
0.0178
-
 Cr3+ pH 7.7, 24°C Chelon saliens
0.018
-
 Cr3+
-
 Chelon saliens
0.0728
-
 Cd2+ pH 7.7, 24°C Chelon saliens
0.073
-
 Cd2+
-
 Chelon saliens
0.329
-
 Ni2+
-
 Chelon saliens
0.329
-
 Ni2+ pH 7.7, 24°C Chelon saliens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00007
-
 0.05 mM, complete inhibition. IC50: 0.00007 mM, noncompetitive inhibition Chelon saliens Hg2+
0.00007
-
 pH 7.7, 24°C Chelon saliens Hg2+
0.024
-
 0.05 mM, 66% inhibition. IC50: 0.024 mM, noncompetitive inhibition Chelon saliens Cd2+
0.024
-
 pH 7.7, 24°C Chelon saliens Cr3+
0.033
-
 0.05 mM,65% inhibition. IC50: 0.033 mM, noncompetitive inhibition Chelon saliens Cr3+
0.033
-
 pH 7.7, 24°C Chelon saliens Cd2+
0.143
-
 0.05 mM, 37% inhibition. IC50: 0.143 mM, noncompetitive inhibition Chelon saliens Ni2+
0.143
-
 pH 7.7, 24°C Chelon saliens Ni2+