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Literature summary for 1.6.2.4 extracted from

  • Gutierrez, A.; Munro, A.W.; Grunau, A.; Wolf, C.R.; Scrutton, N.S.; Roberts, G.C.
    Interflavin electron transfer in human cytochrome P450 reductase is enhanced by coenzyme binding. Relaxation kinetic studies with coenzyme analogues (2003), Eur. J. Biochem., 270, 2612-2621.
    View publication on PubMed
Search for more literature for 1.6.2.4

Activating Compound

Activating Compound Comment Organism Structure
2',5'-ADP increases internal electron transfer in dithionite reduced enzyme Homo sapiens
2'-AMP increases internal electron transfer in dithionite reduced enzyme Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
truncated form lacking the membrane anchoring domain expresed in Escherichia coli BL21(DE3)pLysS Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2',5'-ADP competitive with NADPH Homo sapiens
2'-AMP
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 ferricytochrome P450 + NADPH Homo sapiens involved in drug metabolism 2 ferrocytochrome P450 + NADP+ + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 ferricytochrome c + NADH low rate of internal electron transfer Homo sapiens 2 ferrocytochrome c + NAD+ + H+
-
 ?
2 ferricytochrome c + NADPH
-
 Homo sapiens 2 ferrocytochrome c + NADP+ + H+
-
 ?
2 ferricytochrome P450 + NADPH involved in drug metabolism Homo sapiens 2 ferrocytochrome P450 + NADP+ + H+
-
 ?
ferricytochrome c + dithionite very low rate of internal electron transfer Homo sapiens ferrocytochrome c + ?
-
 ?

Synonyms

Synonyms Comment Organism
NADPH-cytochrome P450 reductase
-
 Homo sapiens
NADPH-ferrihemoprotein reductase
-
 Homo sapiens
NADPH:ferrihemoprotein oxidoreductase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD together with FMN Homo sapiens
FMN together with FAD Homo sapiens
NADPH
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0054
-
 2',5'-ADP pH 7.0, 25°C Homo sapiens
0.18
-
 2'-AMP pH 7.0, 25°C Homo sapiens