Literature summary for 1.6.2.4 extracted from

Pritchard, M.P.; Glancey, M.J.; Blake, J.A.R.; Gilham, D.E.; Burchell, B.; Wolf, C.R.; Friedberg, T.
Functional co-expression of CYP2D6 and human NADPH-cytochrome P450 reductase in Escherichia coli (1998), Pharmacogenetics, 8, 33-42.

Search for more literature for 1.6.2.4

Cloned(Commentary)

Cloned (Comment)	Organism
coexpression with two differently modified CYP2D6 cDNAs in Escherichia coli, 17alpha-2D6 + pJR7 and ompA-2D6 + pJR7	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
spheroplast	-	Homo sapiens	-	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.3	0.7	-	Homo sapiens
0.361	-	coexpression of 17alpha-2D6 + pJR7, supplementation of cultures with delta-aminolevulinic acid	Homo sapiens
0.414	-	coexpression of 17alpha-2D6 + pJR7, without supplementation of cultures with delta-aminolevulinic acid	Homo sapiens
0.517	-	coexpression of ompA-2D6 + pJR7, supplementation of cultures with delta-aminolevulinic acid	Homo sapiens
0.601	-	coexpression of ompA-2D6 + pJR7, without supplementation of cultures with delta-aminolevulinic acid	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2 ferricytochrome c + NADPH	-	Homo sapiens	2 ferrocytochrome c + NADP+ + H+	-	?
additional information	coexpressed with two differently modified CYP2D6 cDNAs in Escherichia coli, functional recombinant monooxygenase, bufuralol and metoprolol metabolism	Homo sapiens	?	-	?

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Release 2023.1 (January 2023)