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Literature summary for 1.6.2.4 extracted from
- Hepatic microsomal ethanol-oxidizing system: solubilization, isolation, and characterization (1974), Arch. Biochem. Biophys., 163, 404-415.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 7.2 | - |
ethanol | microsomal ethanol oxidizing system | Rattus norvegicus |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
Sprague-Dawley strain | - |
| Rattus norvegicus Sprague-Dawley | - |
Sprague-Dawley strain | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.06572 | - |
purified microsomal ethanol-oxidizing system fraction | Rattus norvegicus |
| 0.08572 | - |
microsomes | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2 ferricytochrome c + NADPH | - |
Rattus norvegicus | 2 ferrocytochrome c + NADP+ + H+ | - |
? | |
| 2 ferricytochrome c + NADPH | - |
Rattus norvegicus Sprague-Dawley | 2 ferrocytochrome c + NADP+ + H+ | - |
? | |
| additional information | as part of the microsomal ethanol-oxidizing system composed of NADPH-cytochrome c reductase, cytochrome P-450, phospholipids | Rattus norvegicus | ? | - |
? | |
| additional information | aniline hydroxylase | Rattus norvegicus | ? | - |
? | |
| additional information | N-demethylation of aminopyrine | Rattus norvegicus | ? | - |
? | |
| additional information | N-demethylation of benzphetamine | Rattus norvegicus | ? | - |
? | |
| additional information | as part of the microsomal ethanol-oxidizing system composed of NADPH-cytochrome c reductase, cytochrome P-450, phospholipids | Rattus norvegicus Sprague-Dawley | ? | - |
? | |
| additional information | aniline hydroxylase | Rattus norvegicus Sprague-Dawley | ? | - |
? | |
| additional information | N-demethylation of aminopyrine | Rattus norvegicus Sprague-Dawley | ? | - |
? | |
| additional information | N-demethylation of benzphetamine | Rattus norvegicus Sprague-Dawley | ? | - |
? | |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.9 | 7.5 | microsomal ethanol-oxidizing system | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | - |
Rattus norvegicus | |
| NADPH | not replaceable by NADH | Rattus norvegicus | |
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Release 2023.1 (January 2023)
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