Any feedback?
Literature summary for 1.6.2.4 extracted from
- Ecdysterone biosynthesis: a microsomal cytochrome-P-450-linked ecdysone 20-monooxygenase from tissues of the African migratory locust (1978), Eur. J. Biochem., 88, 37-47.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| NADP+ | - |
Locusta migratoria migratorioides |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.013 | - |
NADPH | - |
Locusta migratoria migratorioides | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Locusta migratoria migratorioides | - |
- |
| mitochondrion | - |
Locusta migratoria migratorioides | 5739 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Locusta migratoria migratorioides | monooxygenase system composed of ecdysone 20-monooxygenase, cytochrome P-450 and NADPH-cytochrome c reductase | ? | - |
? | |
| NADPH + ferricytochrome P450 | Locusta migratoria migratorioides | during ecdysone hydroxylation | ferrocytochrome P450 + NADP+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Locusta migratoria migratorioides | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| fat body | of larvae of both sexes | Locusta migratoria migratorioides | - |
| malpighian tubule | of larvae of both sexes | Locusta migratoria migratorioides | - |
| midgut | of larvae of both sexes | Locusta migratoria migratorioides | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.02 | - |
midgut and hindgut | Locusta migratoria migratorioides |
| 0.029 | - |
malpighian tubules | Locusta migratoria migratorioides |
| 0.051 | - |
fat body | Locusta migratoria migratorioides |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2 ferricytochrome c + NADPH | additional electron acceptor: cytochrome P450 | Locusta migratoria migratorioides | 2 ferrocytochrome c + NADP+ + H+ | - |
? | |
| additional information | hydroxylation of ecdysone | Locusta migratoria migratorioides | ? | - |
? | |
| additional information | monooxygenase system composed of ecdysone 20-monooxygenase, cytochrome P-450 and NADPH-cytochrome c reductase | Locusta migratoria migratorioides | ? | - |
? | |
| NADPH + ferricytochrome P450 | during ecdysone hydroxylation | Locusta migratoria migratorioides | ferrocytochrome P450 + NADP+ | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Locusta migratoria migratorioides | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
