Activating Compound | Comment | Organism | Structure |
---|---|---|---|
H2O2 | 136% increase of activity at 0.5 mM | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-Chloro-7-nitrobenzo-2-oxa-1,3-diazole | 34% residual activity at 1 mM | Homo sapiens | |
palmitoyl CoA | specifically interferes with Nnt activity by competition with NADPH-binding, 20% residual activity at 1 mM | Homo sapiens | |
S-nitrosoglutathione | 100% inhibition at 3 mM or higher concentration | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | inner mitochondrial membrane | Homo sapiens | 5739 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
110000 | - |
SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
NADPH + NAD+ | Homo sapiens | - |
NADP+ + NADH | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q13423 | - |
- |
Purification (Comment) | Organism |
---|---|
Nnt is purified using an immunocapture bead matrix | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
myocardium | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NADPH + 3-acetylpyridine adenine dinucleotide | - |
Homo sapiens | NADP+ + reduced 3-acetylpyridine adenine dinucleotide | - |
? | |
NADPH + NAD+ | - |
Homo sapiens | NADP+ + NADH | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NADPH transhydrogenase | - |
Homo sapiens |
NNT | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | Nnt activity is reduced by 18% in the heart failure | down |