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Literature summary for 1.6.1.2 extracted from

  • Rydström, J.
    Energy-linked nicotinamide nucleotide transhydrogenases (1977), Biochim. Biophys. Acta, 463, 155-184.
    View publication on PubMed
Search for more literature for 1.6.1.2

Activating Compound

Activating Compound Comment Organism Structure
Lipids
-
 Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
5'-AMP
-
 Bos taurus
5'-AMP
-
 Escherichia coli
5'-AMP
-
 Rattus norvegicus
Ca2+
-
 Bos taurus
Ca2+
-
 Rattus norvegicus
Mg2+
-
 Bos taurus
Mg2+
-
 Rattus norvegicus
Mg2+
-
 Rhodospirillum rubrum
Mn2+
-
 Bos taurus
Mn2+
-
 Rattus norvegicus
triiodothyronine
-
 Bos taurus
triiodothyronine
-
 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0065
-
 NADP+ energy-linked reaction Bos taurus
0.009
-
 NADH nonenergy-linked reaction Bos taurus
0.0126
-
 NADH energy-linked reaction Bos taurus
0.02
-
 NADPH nonenergy-linked reaction Bos taurus
0.02
-
 NADPH energy-linked reaction Bos taurus
0.028
-
 NAD+ nonenergy-linked reaction Bos taurus
0.04
-
 NADP+ nonenergy-linked reaction Bos taurus
0.0435
-
 NAD+ energy-linked reaction Bos taurus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
250000
-
-
 Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Escherichia coli
-
-
-
Rattus norvegicus
-
-
-
Rhodospirillum rubrum
-
-
-

Purification (Commentary)

Purification (Comment) Organism
overview of early procedures Bos taurus

Reaction

Reaction Comment Organism Reaction ID
NADPH + NAD+ = NADP+ + NADH mechanism Rattus norvegicus
a
NADPH + NAD+ = NADP+ + NADH mechanism Bos taurus
a
NADPH + NAD+ = NADP+ + NADH mechanism Rhodospirillum rubrum
a
NADPH + NAD+ = NADP+ + NADH enzyme is stereospecific for the 4A hydrogen of NADH and the 4B hydrogen of NADPH Escherichia coli
a
NADPH + NAD+ = NADP+ + NADH enzyme is stereospecific for the 4A hydrogen of NADH and the 4B hydrogen of NADPH Bos taurus
a
NADPH + NAD+ = NADP+ + NADH enzyme is stereospecific for the 4A hydrogen of NADH and the 4B hydrogen of NADPH Rhodospirillum rubrum
a

Renatured (Commentary)

Renatured (Comment) Organism
reconstitution into liposomes Rattus norvegicus
reconstitution into liposomes Bos taurus
reconstitution into liposomes Rhodospirillum rubrum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADH + NADP+ specific for 4A site of NADH, i.e. pro-R hydrogen and 4B site of NADPH, i.e. pro-S hydrogen Escherichia coli NAD+ + NADPH
-
 ?
NADH + NADP+ specific for 4A site of NADH, i.e. pro-R hydrogen and 4B site of NADPH, i.e. pro-S hydrogen Rattus norvegicus NAD+ + NADPH
-
 r
NADH + NADP+ specific for 4A site of NADH, i.e. pro-R hydrogen and 4B site of NADPH, i.e. pro-S hydrogen Bos taurus NAD+ + NADPH
-
 r
NADH + NADP+ specific for 4A site of NADH, i.e. pro-R hydrogen and 4B site of NADPH, i.e. pro-S hydrogen Rhodospirillum rubrum NAD+ + NADPH
-
 r
NADH + thio-NADP+
-
 Rattus norvegicus NAD+ + thio-NADPH
-
 r
NADH + thio-NADP+
-
 Bos taurus NAD+ + thio-NADPH
-
 r
NADH + thio-NADP+
-
 Rhodospirillum rubrum NAD+ + thio-NADPH
-
 r

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Escherichia coli
NAD+
-
 Rattus norvegicus
NAD+
-
 Bos taurus
NAD+
-
 Rhodospirillum rubrum
NADH
-
 Escherichia coli
NADH
-
 Rattus norvegicus
NADH
-
 Bos taurus
NADH
-
 Rhodospirillum rubrum
NADP+
-
 Escherichia coli
NADP+
-
 Rattus norvegicus
NADP+
-
 Bos taurus
NADP+
-
 Rhodospirillum rubrum
NADPH
-
 Escherichia coli
NADPH
-
 Rattus norvegicus
NADPH
-
 Bos taurus
NADPH
-
 Rhodospirillum rubrum