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Literature summary for 1.5.99.4 extracted from
- Rabbit nasal cytochrome P-450 NMa has high activity as a nicotine oxidase (1990), Biochem. Biophys. Res. Commun., 166, 945-952.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.035 | - |
(S)-nicotine | - |
Oryctolagus cuniculus |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | olfactory and respiratory | Oryctolagus cuniculus | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Oryctolagus cuniculus | - |
male, adult, New Zealand White | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| nose | - |
Oryctolagus cuniculus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.0065 | - |
respiratory microsomes | Oryctolagus cuniculus |
| 0.0222 | - |
olfactory microsomes | Oryctolagus cuniculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (S)-nicotine + acceptor | - |
Oryctolagus cuniculus | (S)-nicotine delta1',5'-iminium ion + reduced acceptor | - |
? | |
| (S)-nicotine + acceptor + H2O | - |
Oryctolagus cuniculus | nornicotine + reduced acceptor + ? | - |
? | |
| (S)-nicotine + acceptor + H2O | - |
Oryctolagus cuniculus | nicotine-N-oxide + reduced acceptor | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Oryctolagus cuniculus |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.468 | - |
(S)-nicotine | respiratory | Oryctolagus cuniculus | |
| 0.597 | - |
(S)-nicotine | olfactory | Oryctolagus cuniculus | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Oryctolagus cuniculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| cytochrome P450 | P-450 NMa monooxygenase | Oryctolagus cuniculus | |
| additional information | flavoprotein | Oryctolagus cuniculus |
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Release 2023.1 (January 2023)
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