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Literature summary for 1.5.8.4 extracted from

  • Wittwer, A.J.; Wagner, C.
    Identification of the folate-binding proteins of rat liver mitochondria as dimethylglycine dehydrogenase and sarcosine dehydrogenase. Purification and folate-binding characteristics (1981), J. Biol. Chem., 256, 4102-4108.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Rattus norvegicus 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
90000
-
x * 90000, SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N,N-dimethylglycine + tetrahydropteroylpentaglutamate + acceptor Rattus norvegicus during the reaction tightly bound tetrahydropteroylpentaglutamate is converted to 5,10-methylene tetrahydropteroylpentaglutamate sarcosine + 5,10-methylene tetrahydropteroylpentaglutamate + reduced acceptor
-
?
N,N-dimethylglycine + tetrahydropteroylpentaglutamate + acceptor Rattus norvegicus reaction of the choline degradation pathway sarcosine + 5,10-methylene tetrahydropteroylpentaglutamate + reduced acceptor
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N,N-dimethylglycine + acceptor + H2O acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate Rattus norvegicus sarcosine + formaldehyde + reduced acceptor
-
?
N,N-dimethylglycine + tetrahydropteroylpentaglutamate + acceptor during the reaction tightly bound tetrahydropteroylpentaglutamate is converted to 5,10-methylene tetrahydropteroylpentaglutamate Rattus norvegicus sarcosine + 5,10-methylene tetrahydropteroylpentaglutamate + reduced acceptor
-
?
N,N-dimethylglycine + tetrahydropteroylpentaglutamate + acceptor reaction of the choline degradation pathway Rattus norvegicus sarcosine + 5,10-methylene tetrahydropteroylpentaglutamate + reduced acceptor
-
?

Subunits

Subunits Comment Organism
? x * 90000, SDS-PAGE Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
FAD covalently bound Rattus norvegicus
Tetrahydropteroylpentaglutamate
-
Rattus norvegicus