Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Methoxyacetate | competitive inhibitor at low substrate concentrations | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.05 | - |
dimethylglycine | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Rattus norvegicus | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
N,N-dimethylglycine + tetrahydropteroylpentaglutamate + acceptor | Rattus norvegicus | during the reaction tightly bound tetrahydropteroylpentaglutamate is converted to 5,10-methylene tetrahydropteroylpentaglutamate | sarcosine + 5,10-methylene tetrahydropteroylpentaglutamate + reduced acceptor | - |
? | |
N,N-dimethylglycine + tetrahydropteroylpentaglutamate + acceptor | Rattus norvegicus | reaction of the choline degradation pathway | sarcosine + 5,10-methylene tetrahydropteroylpentaglutamate + reduced acceptor | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.268 | - |
- |
Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N,N-dimethylglycine + acceptor + H2O | acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate | Rattus norvegicus | sarcosine + formaldehyde + reduced acceptor | - |
? | |
N,N-dimethylglycine + tetrahydropteroylpentaglutamate + acceptor | during the reaction tightly bound tetrahydropteroylpentaglutamate is converted to 5,10-methylene tetrahydropteroylpentaglutamate | Rattus norvegicus | sarcosine + 5,10-methylene tetrahydropteroylpentaglutamate + reduced acceptor | - |
? | |
N,N-dimethylglycine + tetrahydropteroylpentaglutamate + acceptor | reaction of the choline degradation pathway | Rattus norvegicus | sarcosine + 5,10-methylene tetrahydropteroylpentaglutamate + reduced acceptor | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.14 | - |
N,N-dimethylglycine | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | covalently bound | Rattus norvegicus | |
Tetrahydropteroylpentaglutamate | - |
Rattus norvegicus |