Crystallization (Comment) | Organism |
---|---|
crystal structure analysis | Sus scrofa |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrial inner membrane | bound to via ubiquinone binding domain, overview | Sus scrofa | 5743 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | a [4Fe-4S]+1+2 cluster | Sus scrofa |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
reduced electron-transferring flavoprotein + ubiquinone | Sus scrofa | electron transfer via flavin cofactor | electron-transferring flavoprotein + ubiquinol | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Sus scrofa | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Sus scrofa | - |
liver | - |
Sus scrofa | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | mechanism of superoxide formation by ETF-QO, reduction potentials of redox centres, overview | Sus scrofa | ? | - |
? | |
reduced electron-transferring flavoprotein + ubiquinone | electron transfer via flavin cofactor | Sus scrofa | electron-transferring flavoprotein + ubiquinol | - |
r |
Synonyms | Comment | Organism |
---|---|---|
electron transfer flavoprotein: ubiquinone oxidoreductase | - |
Sus scrofa |
electron transfer flavoprotein:ubiquinone oxidoreductase | - |
Sus scrofa |
ETF-QO | - |
Sus scrofa |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | the flavin serves as the immediate reductant of ubiquinone | Sus scrofa |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme deficiency can cause multiple acyl-CoA dehydrogenase deficiency, MADD. The inability to oxidize fatty acids prevents the synthesis of ketone bodies, an essential alternate energy source for the heart. Affected individuals frequently die in early infancy with a severe, frequently fatal, metabolic acidosis that is often accompanied by a stress-induced hypertrophic cardiomyopathy and lipid accumulation in the heart, and secondary carnitine deficiency | Sus scrofa |
additional information | the enzyme is a component of the mitochondrial respiratory chain that together with electron transfer flavoprotein (ETF) forms a short pathway that transfers electrons from 11 different mitochondrial flavoprotein dehydrogenases to the ubiquinone pool, ETF:QO enzyme structure and its quinone binding site, domain organisation, overview | Sus scrofa |