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Literature summary for 1.5.5.1 extracted from

  • Chew, D.S.; Mah, A.K.; Baillie, D.L.
    Characterizing the transcriptional regulation of let-721, a Caenorhabditis elegans homolog of human electron flavoprotein dehydrogenase (2009), Mol. Genet. Genomics, 282, 555-570.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
G362E mutation occurs in one of two beta-sheets that form the structure of the FAD binding domain likely disrupting the secondary structur. Phenotype of homozygous let-721 mutant is maternal effects lethality. F1 homozygotes have no gross morphological or developmental defects. The maternal effect lethal manifests as the self-fertilized offspring arrest as unhatched embryos. F1 worms are also self semi-sterile, as unmated homozygous mutants produce significantly fewer embryos than wild-type worms Caenorhabditis elegans
S61F affected residue lies within a conserved domain that interacts with the adenine monophosphate moiety of the FAD prosthetic group. Phenotype of homozygous let-721 mutant is maternal effects lethality. F1 homozygotes have no gross morphological or developmental defects. The maternal effect lethal manifests as the self-fertilized offspring arrest as unhatched embryos. F1 worms are also self semi-sterile, as unmated homozygous mutants produce significantly fewer embryos than wild-type worms Caenorhabditis elegans

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion ETFDH is an inner mitochondrial membrane localized enzyme Caenorhabditis elegans 5739
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Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
gonad RNA transcribed in somatic gonads Caenorhabditis elegans
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hypodermis RNA transcribed Caenorhabditis elegans
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intestine RNA transcribed Caenorhabditis elegans
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muscle RNA transcribed in body wall muscle Caenorhabditis elegans
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pharynx RNA transcribed Caenorhabditis elegans
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Synonyms

Synonyms Comment Organism
electron-transferring flavoprotein dehydrogenase
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Caenorhabditis elegans
ETFDH
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Caenorhabditis elegans
let-721
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Caenorhabditis elegans

General Information

General Information Comment Organism
physiological function three cis-regulatory sequences (pha-site, rep-site, and act-site) are identified. Phylogenetic footprinting of each site indicates that they are conserved between four Caenorhabditis species. Results show that let-721 is under complex transcriptional control Caenorhabditis elegans