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Literature summary for 1.5.3.7 extracted from
- L-Pipecolic acid oxidation in the rabbit and cynomolgus monkey. Evidence for differing organellar locations and cofactor requirements in each species (1989), J. Biol. Chem., 264, 2509-2517.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | activity is maximal when FAD, phenazine ethosulfate and glycerol are included in the assay | Oryctolagus cuniculus |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | L-pipecolic oxidase activity is deficient in patients with peroxisome biogenesis disorders | Oryctolagus cuniculus |
| medicine | L-pipecolic oxidase activity is deficient in patients with peroxisome biogenesis disorders | Macacine alphaherpesvirus 1 |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| antimycin A | - |
Oryctolagus cuniculus |  |
| L-proline | - |
Oryctolagus cuniculus | |
| phenazine ethosulfate | - |
Macacine alphaherpesvirus 1 | |
| rotenone | - |
Oryctolagus cuniculus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.74 | - |
L-pipecolic acid | - |
Oryctolagus cuniculus | |
| 4.2 | - |
L-pipecolic acid | - |
Macacine alphaherpesvirus 1 | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | soluble fraction | Oryctolagus cuniculus | 5739 | - |
| peroxisome | membrane-associated | Macacine alphaherpesvirus 1 | 5777 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-pipecolate + O2 | Oryctolagus cuniculus | - |
2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2 | the product reacts with water to form 2-aminoadipate 6-semialdehyde | ? | |
| L-pipecolate + O2 | Macacine alphaherpesvirus 1 | - |
2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2 | the product reacts with water to form 2-aminoadipate 6-semialdehyde | ? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Macacine alphaherpesvirus 1 | - |
cynomolgus monkey | - |
| Oryctolagus cuniculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Oryctolagus cuniculus | - |
| heart | - |
Oryctolagus cuniculus | - |
| kidney | highest activity in the kidney cortex | Oryctolagus cuniculus | - |
| kidney | highest activity in the kidney cortex | Macacine alphaherpesvirus 1 | - |
| liver | - |
Oryctolagus cuniculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-pipecolate + O2 | - |
Oryctolagus cuniculus | 2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2 | - |
? | |
| L-pipecolate + O2 | - |
Macacine alphaherpesvirus 1 | 2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2 | - |
? | |
| L-pipecolate + O2 | - |
Oryctolagus cuniculus | 2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2 | the product reacts with water to form 2-aminoadipate 6-semialdehyde | ? | |
| L-pipecolate + O2 | - |
Macacine alphaherpesvirus 1 | 2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2 | the product reacts with water to form 2-aminoadipate 6-semialdehyde | ? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.5 | - |
- |
Macacine alphaherpesvirus 1 |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | - |
Oryctolagus cuniculus | |
| FAD | - |
Macacine alphaherpesvirus 1 | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 10 | - |
L-proline | - |
Oryctolagus cuniculus | |
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