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Literature summary for 1.5.3.7 extracted from
- Molecular cloning and expression of human L-pipecolate oxidase (2000), Biochem. Biophys. Res. Commun., 270, 1101-1105.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | L-pipecolic acid is formed by the catabolism of lysine in humans, and its accumulation is one of the first biochemical abnormalities detected in the Zellweger syndrome | Homo sapiens |
| medicine | the L-pipecolate pathway for degradation of lysine is the principal one in the brain | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed as a chimera between maltose-binding protein and L-pipecolic acid oxidase | Homo sapiens |
| expressed in Escherichia coli BL21 | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-pipecolate + O2 | Homo sapiens | - |
2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2 | the product reacts with water to form 2-aminoadipate 6-semialdehyde | ? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-pipecolate + O2 | - |
Homo sapiens | 2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2 | the product reacts with water to form 2-aminoadipate 6-semialdehyde | ? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.7 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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