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Literature summary for 1.5.3.19 extracted from

  • Chiribau, C.; Mihasan, M.; Ganas, P.; Igloi, G.; Artenie, V.; Brandsch, R.
    Final steps in the catabolism of nicotine (2006), FEBS J., 273, 1528-1536.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Paenarthrobacter nicotinovorans
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General Information

General Information Comment Organism
physiological function in nicotine breakdown, two alternative pathways for the final steps in the catabolism of 4-methylaminobutanoate could be identified. 4-Methylaminobutanoate may be demethylated to gamma-N-aminobutyrate by gamma-N-methylaminobutanoate oxidase, EC 1.5.3.19. In an alternative pathway, amine oxidase, EC 1.5.3.21, removes methylamine from 4-methylaminobutanoate with the formation of succinic semialdehyde. Kinetic analyses suggest that demethylation predominates over deamination of 4-methylaminobutanoate Paenarthrobacter nicotinovorans