Inhibitors | Comment | Organism | Structure |
---|---|---|---|
dithioerythritol | up to 0.010 mM increase the enzyme activity, higher concentrations inhibit | Ascaris suum | |
dithiothreitol | up to 0.010 mM increase the enzyme activity, higher concentrations inhibit | Ascaris suum | |
Iproniazid | 0.01 mM, 87% inhibition | Ascaris suum | |
isoniazid | 0.01 mM, 81% inhibition | Ascaris suum | |
MDL 27391 | - |
Ascaris suum | |
MDL 27695 | - |
Ascaris suum | |
additional information | the polyamine oxidase inhibitor MDL 72527 has no effect on the parasite polyamine oxidase activity | Ascaris suum | |
NEM | 0.01 mM, 85% inhibition | Ascaris suum |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.35 | - |
spermine | pH 8.5, 37°C | Ascaris suum | |
0.66 | - |
spermidine | pH 8.5, 37°C | Ascaris suum | |
1.6 | - |
benzylamidine | pH 8.5, 37°C | Ascaris suum | |
2 | - |
norspermine | pH 8.5, 37°C | Ascaris suum | |
2.5 | - |
tryptamine | pH 8.5, 37°C | Ascaris suum | |
5 | - |
norspermidine | pH 8.5, 37°C | Ascaris suum |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
additional information | copper and iron are not cofactors | Ascaris suum |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
66000 | - |
x * 66000, SDS-PAGE | Ascaris suum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Ascaris suum | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Ascaris suum |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
2.3 | - |
- |
Ascaris suum |
Storage Stability | Organism |
---|---|
-20°C, stable for 2 days (minimal loss of activity), complete loss of enzyme activity after 14 days | Ascaris suum |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
benzylamidine + O2 + H2O | - |
Ascaris suum | ? | - |
? | |
additional information | N-acetylated polyamines and diamines, e.g. N1-acetylspermidine, N8-acetylspermidine, N-acetylspermine, N1,N12-diacetylspermine, putrescine, cadaverine and histamine, are not accepted as substrates. Bis(benzyl)polyamines, such as MDL 27695 and MDL 27391, are not substrates | Ascaris suum | ? | - |
? | |
norspermidine + O2 + H2O | - |
Ascaris suum | ? | - |
? | |
norspermine + O2 + H2O | - |
Ascaris suum | ? | - |
? | |
spermidine + O2 + H2O | - |
Ascaris suum | putrescine + 3-aminopropanal + H2O2 | - |
? | |
spermine + O2 + H2O | - |
Ascaris suum | spermidine + 3-aminopropanal + H2O2 | - |
? | |
tryptamine + O2 + H2O | - |
Ascaris suum | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 66000, SDS-PAGE | Ascaris suum |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
60 min, complete loss of activity | Ascaris suum |
37 | - |
60 min, complete loss of activity | Ascaris suum |
42 | - |
60 min, complete loss of activity | Ascaris suum |
56 | - |
60 min, complete loss of activity | Ascaris suum |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.5 | - |
- |
Ascaris suum |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Ascaris suum |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.02 | - |
MDL 27695 | pH 8.5, 37°C | Ascaris suum |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Ascaris suum | isoelectric focusing | - |
7.8 |